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Characterizing the phenotypic manifestations of MFN2 R104W mutation in Charcot-Marie-Tooth type 2
(PERGAMON-ELSEVIER SCIENCE LTD, 2011)
Mutations of the mitofusin 2 (MFN2) gene have been reported to be the most common cause of the axonal form of Charcot Marie Tooth disease (CMT). The aim of this study was to describe a de novo MFN2 p.R104W mutation and ...
Mfn2 deficiency links age-related sarcopenia and impaired autophagy to activation of an adaptive mitophagy pathway
(Nature Publishing Group, 2016-08)
Mitochondrial dysfunction and accumulation of damaged mitochondria are considered major contributors to aging. However, the molecular mechanisms responsible for these mitochondrial alterations remain unknown. Here, we ...
CFTR chloride channel activity modulates the mitochondrial morphology in cultured epithelial cells
(Elsevier, 2021)
Abstract: The impairment of the CFTR channel activity, a cAMP-activated chloride (Cl− ) channel responsible for cystic
fibrosis (CF), has been associated with a variety of mitochondrial alterations such as modified gene ...
Acute leukemias in Piauí: comparison with features observed in other regions of Brazil
(Associação Brasileira de Divulgação Científica, 2003)
Acute leukemias in Piaui: comparison with features observed in other regions of Brazil
(Assoc Bras Divulg CientificaSao PauloBrasil, 2003)
Changes in mitochondrial dynamics during ceramide-induced cardiomyocyte early apoptosis
(ELSEVIER SCIENCE BV, 2008-01-15)
Aims In cells, mitochondria are organized as a network of interconnected organelles that fluctuate between fission and fusion events (mitochondrial dynamics). This process is associated with cell death. We investigated ...
Mitochondrial fragmentation impairs insulin-dependent glucose uptake by modulating Akt activity through mitochondrial Ca2+ uptake
(American Physiological Society, 2014)
Insulin is a major
regulator of glucose metabolism, stimulating its mitochondrial oxidation
in skeletal muscle cells. Mitochondria are dynamic organelles that
can undergo structural remodeling in order to cope with these ...