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Review article: Shared disease mechanisms between non-alcoholic fatty liver disease and metabolic syndrome – translating knowledge from systems biology to the bedside
(Wiley Blackwell Publishing, Inc, 2019-03)
Background/Aim: Non-alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease worldwide. Characterised by abnormal fat accumulation in the liver, NAFLD presents high degree of comorbidity with ...
MAFLD: A Consensus-Driven Proposed Nomenclature for Metabolic Associated Fatty Liver Disease
(W B Saunders Co-Elsevier Inc, 2020-05)
Fatty liver associated with metabolic dysfunction is common, affects a quarter of the population, and has no approved drug therapy. Although pharmacotherapies are in development, response rates appear modest. The heterogeneous ...
Cholesterol in brain disease: sometimesdeterminant and frequently implicated
(Nature Publishing Group, 2014-09)
Cholesterol is essential for neuronal physiology, both during development and in the adult life: as a major component of cell membranes and precursor of steroid hormones, it contributes to the regulation of ion permeability, ...
Investigation of inborn errors of metabolismInvestigação de erros inatos do metabolismo
(HCPA/FAMED/UFRGS, 2022)
Nonalcoholic fatty liver disease and metabolic syndrome: Shared genetic basis of pathogenesis
(John Wiley & Sons Inc, 2016-11)
A growing body of evidence indicates that nonalcoholic fatty liver disease (NAFLD) develops from a complex process that includes genetic susceptibility and environmental exposure. Regardless of whether it is the cause or ...
Metabolic profiling reveals that PNPLA3 induces widespread effects on metabolism beyond triacylglycerol remodeling in Huh-7 hepatoma cells
(American Physiological Society, 2014-07)
PNPLA3 was recently associated with the susceptibility to nonalcoholic fatty liver disease, a common cause of chronic liver disease characterized by abnormal triglyceride accumulation. Although it is established that PNPLA3 ...
Overweight and obesity: a review of their relationship to metabolic syndrome, cardiovascular disease, and cancer in South America
(Wiley, 2013-03)
Socioeconomic and demographic transformations are occurring very rapidly in some areas of the world, especially in South America, and are accompanied by changes in lifestyle, dietary patterns, and the epidemiological profile ...
Circulating MicroRNA-122 signature in nonalcoholic fatty liver disease and cardiovascular disease: A new endocrine system in metabolic syndrome
(John Wiley & Sons Inc, 2013-06)
To the Editor: We read with great interest the article by Bala et al. about the role of circulating microRNAs (miRNAs) as markers of alcohol‐ and acetaminophen‐induced liver damage in a mouse model; the investigators ...
Diminished Prolinemia in Chronic Chagasic Patients: A New Clue for Disease Pathology?
(MDPI, 2019-08)
Trypanosoma cruzi, the etiological agent of Chagas disease, is dependent on proline for a variety of processes, such as energy metabolism, host cell invasion, differentiation, and resistance to osmotic, metabolic, and ...
Metabolic and Growth Rate Alterations in Lymphoblastic Cell Lines Discriminate between Down Syndrome and Alzheimer's Disease
(IOS Press, 2016-08)
Deficits in mitochondrial function and oxidative stress play pivotal roles in Down syndrome (DS) and Alzheimer's disease (AD) and these alterations in mitochondria occur systemically in both conditions. Objective: We ...