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Expression of Circadian Clock and Melatonin Receptors within Cultured Rat Cardiomyocytes
(INFORMA HEALTHCARE, 2011)
Melatonin, the pineal gland hormone, provides entrainment of many circadian rhythms to the ambient light/dark cycle. Recently, cardiovascular studies have demostrated melatonin interactions with many physiological processes ...
Are melatonin doses employed clinically adequate for melatonin-induced cytoprotection?
(ST BIo-Life, 2019)
Abstract: This review article discusses the special role that melatonin, a molecule with chronobiotic/cytoprotective properties, may have in prevention and treatment of the metabolic ...
Evaluation of melatonin treatment in primary culture of canine mammary tumors
(Spandidos Publ Ltd, 2015-01-01)
Mammary neoplasias are the most common tumors observed in female dogs. Identification of these tumors is valuable in order to identify beneficial therapeutic agents as alternative treatments for this tumor type. Oral ...
Day/night melatonin content in cerebral palsy
(2018-11-01)
Changes in the sleep-wake cycle are frequent and may impair quality of life in individuals with cerebral palsy (CP). To investigate if a lack of a day/night variation of melatonin content could be related with sleep disorders ...
Local actions of melatonin in somatic cells of the testis
(MDPI AG, 2017-06)
The pineal hormone melatonin regulates testicular function through the hypothalamic- adenohypophyseal axis. In addition, direct actions of melatonin in somatic cells of the testis have been described. Melatonin acts as a ...
The co-catalytic effect of chlorpromazine on peroxidase-mediated oxidation of melatonin: enhanced production of N-1-acetyl-N (2)-formyl-5-methoxykynuramine
(Blackwell Publishing, 2008-03-01)
Accumulating evidence points to relationships between increased production of reactive oxygen or decreased antioxidant protection in schizophrenic patients. Chlorpromazine (CPZ), which remains a benchmark treatment for ...
Melatonin and its kynurenin-like oxidation products affect the microbicidal activity of neutrophils
(Elsevier B.V., 2006-02-01)
Activated phagocytes oxidize the hormone melatonin to N-1-acethyl-N-2-formyl-5-methoxykynuramine (AFMK) in a superoxide anion- and myeloperoxidase-dependent reaction. We examined the effect of melatonin, AFMK and its ...
Oxidation of melatonin by taurine chloramine
(Wiley-Blackwell, 2010-09-01)
Melatonin is widely known for its antioxidant, immunomodulatory, and anti-inflammatory effects. Hypochlorous acid (HOCl) is one example of an endogenous oxidant that is promptly neutralized by melatonin. Melatonin also ...
Melatonin therapy in patients with Alzheimer’s disease
(Multidisciplinary Digital Publishing Institute, 2014-04)
Alzheimer’s disease (AD) is a major health problem and a growing recognition exists that efforts to prevent it must be undertaken by both governmental and non-governmental organizations. In this context, the pineal product, ...
Oxidation of melatonin by AAPH-derived peroxyl radicals: Evidence of a pro-oxidant effect of melatonin
(Elsevier B.V., 2009-08-01)
Background: Melatonin is well-established as a powerful reducing agent of oxidant generated in the cell medium. We aimed to investigate how readily melatonin is oxidized by peroxyl radicals ROO(-) generated by the thermolysis ...