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A low maternal protein diet during pregnancy and lactation induce liver offspring damage, in the rat
(Austin Publishing Group, 2015-01)
Pregnancy and fetal development are periods of rapid growth and cell differentiation when mother and offspring are vulnerable to changes. Adverse events during development can be linked to an increased risk for developing ...
Chronic hepatitis C virus infection: Serum biomarkers in predicting liver damage
(W J G Press, 2016-01)
Currently, a major clinical challenge in the management of the increasing number of hepatitis C virus (HCV) infected patients is determining the best means for evaluating liver impairment. Prognosis and treatment of chronic ...
Cardiovascular disease is associated with high-fat-diet-induced liver damage and up-regulation of the hepatic expression of hypoxia-inducible factor 1α in a rat model
(Portland Press, 2013-01)
CVD (cardiovascular disease) is associated with abnormal liver enzymes, and NAFLD (non-alcoholic fatty liver disease) is independently associated with cardiovascular risk. To gain insights into the molecular events underlying ...
Alternation between dietary protein depletion and normal feeding cause liver damage in mouse
(Servicio Publicaciones Universidad Navarra, 2011-03)
The effect of frequent protein malnutrition on liver function has not been intensively examined. Thus, the effects of alternating 5 days of a protein and amino acid-free diet followed by 5 days of a complete diet repeated ...
Smallanthus sonchifolius roots ameliorate non-alcoholic fatty liver disease by reducing redox imbalance and hepatocyte damage in rats fed with a high fructose diet
(Wolters Kluwer Medknow Publications, 2019-09)
Objective: To evaluate the potential of Smallanthus sonchifolius (S. sonchifolius) roots in ameliorating hepatic damage of rats fed with a high fructose diet. Methods: The effect of S. sonchifolius roots on energy intake, ...
Kidney liver pathophysiological crosstalk: its characteristics and importance
(Springer, 2019-12)
The kidney plays a crucial role in controlling the blood volume and pressure, electrolyte and acid–base balance, erythropoietin secretion, as well as renin–angiotensin–aldosterone system activity. All these renal activities ...
Liver mitochondrial DNA damage and genetic variability of Cytochrome b – a key component of the respirasome – drive the severity of fatty liver disease
(Wiley Blackwell Publishing, Inc, 2020-07-07)
Background and aims: The progression of nonalcoholic fatty liver disease (NAFLD) into severe histological forms (steatohepatitis – NASH) is paralleled by the occurrence of complex molecular processes. Mitochondrial dysfunction ...
Taking advantage of the potential of mesenchymal stromal cells in liver regeneration: Cells and extracellular vesicles as therapeutic strategies
(W J G Press, 2018-06)
Cell-based therapies for acute and chronic liver diseases are under continuous progress. Mesenchymal stem/stromal cells (MSCs) are multipotent cells able to migrate selectively to damaged tissue and contribute to its healing ...
Editorial: Advances in Liver Inflammation and Fibrosis due to Infectious Diseases
(Frontiers Media S.A., 2020-07)
Liver inflammation is a common trigger of hepatic disease, and it is considered the main driver of tissue damage (1). Although the liver is able to regenerate, chronic liver inflammation leads to tissue damage with concomitant ...
SPARC gene deletion protects against toxic liver injury and is associated to an enhanced proliferative capacity and reduced oxidative stress response
(Impact Journals, 2016-05)
SPARC, also known as osteonectin and BM-40, is a matricellular protein with a number of biological functions. Hepatic SPARC expression is induced in response to thioacetamide, bile-duct ligation, and acute injuries such ...