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LRRK-2 as a Key Molecule Bridging Inflammation to Parkinson's Disease
(IOS Press, 2013-11)
The pathogenetic mechanisms leading to typical Parkinson's Disease (PD), the second most common human neurodegenerative disorder remains unknown. Genetic variants of Leucine-Rich Repeat Kinase 2 (LRRK-2) are associated ...
Olfactory Heterogeneity in LRRK2 Related Parkinsonism
(WILEY-LISS, 2010)
LRRK2 mutations can cause familial and sporadic Parkinson`s disease (PD) with Lewy-body pathology at post-mortem. Studies of olfaction in LRRK2 are sparse and incongruent. We applied a previously validated translation of ...
Lrrk2 p.Q1111H substitution and Parkinson's disease in Latin America
(2011)
Mutations in the LRRK2 gene are the most common genetic cause of Parkinson's disease, with frequencies displaying a high degree of population-specificity. Although more than 100 coding substitutions have been identified, ...
QSAR Modelling to Identify LRRK2 Inhibitors for Parkinson's Disease
(De Gruyter, 2019-02-14)
Parkinson's disease is one of the most common neurodegenerative illnesses in older persons and the leucine-rich repeat kinase 2 (LRRK2) is an auspicious target for its pharmacological treatment. In this work, quantitative ...
Investigação das mutações do gene LRRK2 como fator de risco para a doença de Parkinson: revisão sistemática com metanálise
(2013-05-17)
A Doença de Parkinson (DP) é a segunda enfermidade neurodegenerativa mais freqüente no mundo e, não obstante sua epidemiologia significativa, poucos são os achados sobre suas causas apesar das inúmeras pesquisas sobre o ...
Inflexible Ethanol Intake: A Putative Link With The Lrrk2 Pathway
(Elsevier Science BVAmsterdam, 2016)
Lrrk2 p.q1111h substitution and parkinsons disease in latin america
(ELSEVIER SCIENCE LONDON, 2011)