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Myocardial remote ischemic preconditioning: from cell biology to clinical application
(Springer, 2021-10)
Remote ischemic preconditioning (rIPC) is a cardioprotective phenomenon where brief periods of ischemia followed by reperfusion of one organ/tissue can confer subsequent protection against ischemia/reperfusion injury in ...
Cardiac ischemic preconditioning prevents dystrophin proteolysis by MMP-2 inhibition
(Instituto de Histología y Embriología, 2016-09)
Dystrophin is a membrane-associated protein responsible for structural stability of the sarcolemma in cardiac myocytes and is very sensitive to ischemic damage. The goal of our study was to determine if ischemic preconditioning ...
Role of thioredoxin-1 in ischemic preconditioning, postconditioning and aged ischemic hearts
(Academic Press Ltd - Elsevier Science Ltd, 2016-07)
Thioredoxin is one of the most important cellular antioxidant systems known to date, and is responsible of maintaining the reduced state of the intracellular space. Trx-1 is a small cytosolic protein whose transcription ...
Induction of ischemic tolerance as a promising treatment against diabetic retinopathy
(Medknow Publications, 2014-09)
Diabetic retinopathy is a leading cause of acquired blindness, and it is the most common ischemic disorder of the retina. Available treatments are not very effective. Efforts to inhibit diabetic retinopathy have focused ...
Protecting the heart from ischemia/reperfusion injury: an update on remote ischemic preconditioning and postconditioning
(Lippincott Williams, 2017-11-01)
Purpose of review: The most effective strategy for reducing acute myocardial ischemic injury is timely and effective reperfusion. However, myocardial reperfusion can induce further cardiomyocyte death (reperfusion injury). ...
Cyclosporine-A mimicked the ischemic pre- and postconditioning-mediated cardioprotection in hypertensive rats: Role of PKCε
(Academic Press Inc Elsevier Science, 2016-04)
Our aim was to assess the action of cyclosporine-A (CsA) against reperfusion injury in spontaneously hypertensive rats (SHR) compared to the effects of ischemic pre- (IP) and postconditioning (IPC), examining the role ...
High cholesterol diet effects on ischemia- reperfusion injury of the heart
(National Research Council Canada-NRC Research Press, 2012-09)
Ischemic heart disease is the leading cause of morbi-mortality in developed countries. Both ischemia-reperfusion injury and mechanisms of cardioprotection have been studied for more than 50 years. It is known that the ...
Gsk-3 β inhibitors mimic the cardioprotection mediated by ischemic pre- and postconditioning in hypertensive rats
(Hindawi Publishing Corporation, 2013-10)
The aim of this study was to examine the effects of GSK-3β inhibitors compared with PRE and POS in spontaneously hypertensive rats (SHR). Isolated hearts were submitted to the following protocols: IC: 45 min global ischemia ...
Effects of wortmannin on cardioprotection exerted by ischemic preconditioning in rat hearts subjected to ischemia-reperfusion
(Servicio Publicaciones Universidad Navarra, 2016-03)
Ischemic preconditioning (IPC) is one of the most powerful interventions to reduce ischemia-reperfusion injury. The aim of the present study was to investigate the involvement of the phosphatidylinositol-3-kinases (PI3Ks) ...
Adenosine A1 receptors and mitochondria: targets of remote ischemic preconditioning
(American Physiological Society, 2019-03)
Adenosine is involved in classic preconditioning in most species and acts especially through adenosine A1 and A3 receptors. The aim of the present study was to evaluate whether remote ischemic preconditioning (rIPC) activates ...