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The integrity of the α-helical domain of intestinal fatty acid binding protein is essential for the collision-mediated transfer of fatty acids to phospholipid membranes
(Elsevier Science, 2008-04)
Intestinal FABP (IFABP) and liver FABP (LFABP), homologous proteins expressed at high levels in intestinal absorptive cells, employ markedly different mechanisms of fatty acid transfer to acceptor model membranes. Transfer ...
Two crystal forms of a helix-rich fatty acid- and retinol-binding protein, Na-FAR-1, from the parasitic nematode Necator americanus
(Wiley Blackwell Publishing, Inc, 2012-07)
Na-FAR-1 is an unusual -helix-rich fatty acid- and retinol-binding protein from Necator americanus, a blood-feeding intestinal parasitic nematode of humans. It belongs to the FAR protein family, which is unique to nematodes; ...
Structure and ligand binding of As-p18, an extracellular fatty acid binding protein from the eggs of a parasitic nematode
(Portland Press, 2019-07)
Intracellular lipid-binding proteins (iLBPs) of the fatty acid-binding protein (FABP) family of animals transport, mainly fatty acids or retinoids, are confined to the cytosol and have highly similar 3D structures. In ...
Liver fatty acid-binding protein binds monoacylglycerol in vitro and in mouse liver cytosol.
(American Society for Biochemistry and Molecular Biology, 2013-05-08)
Liver fatty acid-binding protein (LFABP; FABP1) is expressed both in liver and intestinal mucosa. Mice null for LFABP were recently shown to have altered metabolism of not only fatty acids but also monoacylglycerol, the ...
Mechanisms underlying reduced weight gain in intestinal fatty acid-binding protein (IFABP) null mice
(American Physiological Society, 2020-02-27)
Intestinal- fatty acid binding protein (IFABP; FABP2) is a 15-kDa intracellular protein abundantly present in the cytosol of the small intestinal (SI) enterocyte. High-fat (HF) feeding of IFABP-/- mice resulted in reduced ...
Free fatty acid receptor 3 is a key target of short chain fatty acid. What is the impact on the sympathetic nervous system?
(Landes Bioscience, 2014-04)
Nervous system (NS) activity participates in metabolic homeostasis by detecting peripheral signal molecules derived from food intake and energy balance. High quality diets are thought to include fiber-rich foods like whole ...
Serum Markers Associated with Severity and Outcome of Hantavirus Pulmonary Syndrome
(University of Chicago Press, 2019-01)
BACKGROUND:Hantavirus pulmonary syndrome (HPS) is caused by Andes virus (ANDV) and related hantaviruses in the Americas. Despite a fatality rate of 40%, the pathogenesis of HPS is poorly understood and factors associated ...
FABP1 knockdown in human enterocytes impairs proliferation and alters lipid metabolism
(Elsevier Science, 2017-12)
Fatty Acid-Binding Proteins (FABPs) are abundant intracellular proteins that bind long chain fatty acids (FA) and have been related with inmunometabolic diseases. Intestinal epithelial cells express two isoforms of FABPs: ...
Truncation of a β-barrel scaffold dissociates intrinsic stability from its propensity to aggregation
(Cell Press, 2012-11)
Δ98Δ is a functional all-β sheet variant of intestinal fatty acid binding protein (IFABP) that was generated by controlled proteolysis. This framework is useful to study the molecular determinants related to aggregation ...
Liver X receptor-α activation enhances cholesterol secretion in lactating mammary epithelium
(American Physiological Society, 2019-06)
Liver X receptors (LXRs) are li-gand-dependent transcription factors activated by cholesterol metabolites. These receptors induce a suite of target genes required for de novo synthesis of triglycerides and cholesterol ...