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A new molecular screening tool for the detection of chromosomal abnormalities in donkeys
(Wiley Blackwell Publishing, Inc, 2019-03)
Chromosomal abnormalities are a major cause of infertility and reproductive problems in equids. Nowadays, their detection is rising due to the use of new diagnostic tools based on molecular markers instead of karyotyping. ...
Correlation between chromosome damage and apoptosis induced by fludarabine and idarubicin in normal human lymphocytes
(Elsevier Ireland, 2002-02)
Fludarabine (FLU, a fluorinated purine analog) and idarubicin (IDA, a DNA-topoisomerase II poison) are frequently used in cancer chemotherapy. The effects of these drugs on cultured normal human lymphocytes were studied ...
Analysis of basal chromosome instability in patients with chronic lymphocytic leukaemia
(Oxford University Press, 2019-04)
Genomic instability is a hallmark of cancer, contributing to tumour development and transformation, being chromosome instability (CIN) the most common form in human cancer. Chronic lymphocytic leukaemia (CLL) is the most ...
Suppressing aneuploidy-associated phenotypes improves the fitness of Trisomy 21 Cells
(Elsevier B.V., 2019-11)
An abnormal number of chromosomes, or aneuploidy, accounts for most spontaneous abortions, causes developmental defects, and is associated with aging and cancer. The molecular mechanisms by which aneuploidy disrupts cellular ...
Focal spermatogenesis originated in euploid germ cells in classical Klinefelter patients.
(Oxford University Press, 2009-05)
background: Klinefelter syndrome is the most frequent chromosome abnormality in human males. This paper aims to investigate the ploidy of meiotic and pre-meiotic germ cells found in spermatogenic foci, and furthermore, the ...
Selective advantage of euploid spermatocytes i in an azoospermic 47,XYY man with gonadal mosaicism
(Oxford University Press, 2019-03)
Although most XYY men have normal sperm counts and are fertile (supposedly due to the loss of the extra Y before meiosis), there is a minority who are infertile. In these cases, the XYY spermatocytes are able to enter ...