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Comparative effects of histone deacetylases inhibitors and resveratrol on Trypanosoma cruzi replication, differentiation, infectivity and gene expression
(Elsevier, 2017-04)
Histone post-translational modification, mediated by histone acetyltransferases and deacetylases, is one of the most studied factors affecting gene expression. Recent data showing differential histone acetylation states ...
Histone methylations in the developing central nervous system and in neural tube defects
(De Gruyter, 2018-05)
Understanding central nervous system genesis is of crucial relevance to decode different human diseases such as microcephaly or neural tube defects, which arise from incorrect developmental processes. Epigenetic mechanisms ...
An integrative analysis of post-translational histone modifications in the marine diatom Phaeodactylum tricornutum
(BioMed Central, 2015)
Background:
Nucleosomes are the building blocks of chromatin where gene regulation takes place. Chromatin landscapes have been profiled for several species, providing insights into the fundamental mechanisms of ...
Heterogeneous distribution of histone methylation in mature human sperm
(Springer, 2014-01-31)
Purpose
To analyze the presence of various histone modifications in ejaculated human spermatozoa
Methods
In this prospective study, seminal ejaculates from 39 normozoospermic individuals were evaluated for semen analysis ...
Dopamine Receptor D1 Contributes to Cocaine Epigenetic Reprogramming of Histone Modifications in Male Germ Cells
(Frontiers Media S.A., 2020-04-03)
Paternal environmental perturbations, including cocaine intake, can affect the development and behavior of the offspring through epigenetic inheritance. However, the mechanism by which cocaine alters the male germ cells ...
Splicing-associated chromatin signatures: a combinatorial and position-dependent role for histone marks in splicing definition
(Nature Research, 2021-12)
Alternative splicing relies on the combinatorial recruitment of splicing regulators to specific RNA binding sites. Chromatin has been shown to impact this recruitment. However, a limited number of histone marks have been ...
Insulin resistance and epigenetic regulation: insights from human studies and prospects for future research
(De Gruyter, 2011-12)
In this study, we review the current knowledge and recent insights on the role of epigenetic factors in the development of human insulin resistance (IR)- and metabolic syndrome (MS)-related phenotypes, and attempt to lay ...
Nuclear factor κB-dependent histone acetylation is specifically involved in persistent forms of memory
(Society for Neuroscience, 2013-04)
Memory consolidation requires gene expression regulation by transcription factors, which eventually may induce chromatin modifications as histone acetylation. This mechanism is regulated by histone acetylases and deacetylases. ...
Epigenetic Changes Associated With Exposure to Glyphosate-Based Herbicides in Mammals
(Frontiers Media, 2021-05)
Glyphosate is a phosphonomethyl amino acid derivative present in a number of non-selective and systemic herbicides. During the last years the use of glyphosate-based herbicide (GBH) has been increasing exponentially around ...