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Assessing the fractions of tautomeric forms of the imidazole ring of histidine in proteins as a function of pH
(National Academy of Sciences, 2011-04-05)
A method is proposed to determine the fraction of the tautomeric forms of the imidazole ring of histidine in proteins as a function of pH, provided that the observed and chemical shifts and the protein structure, or the ...
Unravelling the Photoprotection Capacity of Resveratrol on Histidine Oxidation
(Multidisciplinary Digital Publishing Institute, 2021-11)
Exposure to sun radiation causes great oxidative stress and activates a numerous of defense mechanisms in living systems, such as the synthesis of antioxidants. Resveratrol (RSV), a naturally occurring stilbene molecule, ...
Conformational and Reaction Dynamic Coupling in Histidine Kinases: Insights from Hybrid QM/MM Simulations
(American Chemical Society, 2020-02)
Histidine kinases (HK) of bacterial two-component systems represent a hallmark of allosterism in proteins, being able to detect a signal through the sensor domain and transmit this information through the protein matrix ...
A comprehensive analysis of the computed tautomer fractions of the imidazole ring of histidines in Loligo vulgaris
(Adenine Press, 2017-09)
A recently introduced electrostatic-based method to determine the pKa values of ionizable residues and fractions of ionized and tautomeric forms of histidine (His) and acid residues in proteins, at a given fixed pH, is ...
Multiscale approach to the activation and phosphotransfer mechanism of CpxA histidine kinase reveals a tight coupling between conformational and chemical steps
(Academic Press Inc Elsevier Science, 2018-03)
Sensor histidine kinases (SHKs) are an integral component of the molecular machinery that permits bacteria to adapt to widely changing environmental conditions. CpxA, an extensively studied SHK, is a multidomain homodimeric ...
Crystallization and initial X-ray diffraction analysis of the multi-domain Brucella blue light-activated histidine kinase LOV-HK in its illuminated state
(Elsevier, 2018-12)
The pathogenic bacterium Brucella abortus codes for a multi-domain dimeric cytoplasmic histidine kinase called LOV-HK, which is a key blue light-activated virulence factor in this microorganism. The structural basis of the ...
Limiting values of the one-bond C[sbnd]H spin-spin coupling constants of the imidazole ring of histidine at high-pH
(Elsevier Science, 2017-04)
Assessment of the relative amounts of the forms of the imidazole ring of Histidine (His), namely the protonated (H+) and the tautomeric Nε2-H and Nδ1-H forms, respectively, is a challenging task in NMR spectroscopy. Indeed, ...
The β-scaffold of the LOV domain of the brucella light-activated histidine kinase is a key element for signal transduction
(Academic Press Ltd - Elsevier Science Ltd, 2012-06)
Light-oxygen-voltage (LOV) domains are blue-light-activated signaling modules present in a wide range of sensory proteins. Among them, the histidine kinases are the largest group in prokaryotes (LOV-HK). Light modulates ...
Light regulates attachment, exopolysaccharide production, and nodulation in Rhizobium leguminosarum through a LOV-histidine kinase photoreceptor
(National Academy Of Sciences, 2012-07)
Rhizobium leguminosarum is a soil bacterium that infects root hairs and induces the formation of nitrogen-fixing nodules on leguminous plants. Light, oxygen, and voltage (LOV)-domain proteins are blue-light receptors found ...
Functional Characterization of a LOV-Histidine Kinase Photoreceptor from Xanthomonas citri subsp. citri
(Wiley Blackwell Publishing, Inc, 2015)