Buscar
Mostrando ítems 1-10 de 64
Adaptive Potential of the Heme Oxygenase/Carbon Monoxide Pathway During Hypoxia
(Frontiers Media, 2020)
Heme oxygenase (HO) enzymes catalyze heme into biliverdin, releasing carbon monoxide (CO) and iron into circulation. These byproducts of heme degradation can have potent cytoprotective effects in the face of stressors such ...
HmuS and HmuQ of Ensifer/Sinorhizobium meliloti degrade heme in vitro and participate in heme metabolism in vivo
(Springer, 2016-04)
Ensifer meliloti is a nitrogen-fixing symbiont of the alfalfa legume able to use heme as an iron source. The transport mechanism involved in heme acquisition in E. meliloti has been identified and characterized, but the ...
Heme oxygenase activity and oxidative stress signalling in soybean leaves
(Elsevier Ireland, 2006-02)
We have previously demonstrated that the induction of heme oxygenase-1 (EC 1.14.99.3) plays a protective role for soybean plants against oxidative stress. Here, we have investigated for the first time the possible signal ...
Behavior of antioxidant defense system and heme oxygenase-1protein expression in fructose-hypertensive rats
(Wiley Blackwell Publishing, Inc, 2006-12)
1. Addition of fructose to a rat diet for various time periods leads to hypertension, hyperinsulinemia and dyslipidemia and provides a model for testing oxidative stress parameters in the animals. 2. The oxidative stress ...
Immune modulation by inhibitors of the HO system
(MDPI AG, 2021-01)
The heme oxygenase (HO) system involves three isoforms of this enzyme, HO-1, HO-2, and HO-3. The three of them display the same catalytic activity, oxidating the heme group to produce biliverdin, ferrous iron, and carbon ...
Sevoflurane: Its action on heme metabolism and phase I drug metabolizing system
(C M B Association, 2009-12)
Acute attacks of porphyria are most commonly precipitated by events that decrease heme concentrations. Enzyme inducing-drugs are the most important triggering factors, particularly in relation to anaesthesia. We have ...
Naturally Derived Heme-Oxygenase 1 Inducers and Their Therapeutic Application to Immune-Mediated Diseases
(Frontiers Media S.A., 2020-07)
Heme oxygenase (HO) is the primary antioxidant enzyme involved in heme group degradation. A variety of stimuli triggers the expression of the inducible HO-1 isoform, which is modulated by its substrate and cellular stressors. ...
Nuclear localization of heme oxygenase-1 in pathophysiological conditions: Does it explain the dual role in cancer?
(Multidisciplinary Digital Publishing Institute, 2021-01)
Heme Oxygenase-1 (HO-1) is a type II detoxifying enzyme that catalyzes the rate-limiting step in heme degradation leading to the formation of equimolar quantities of carbon monoxide (CO), free iron and biliverdin. HO-1 was ...
Heme Oxygenase-1 protects astroglia against manganese-induced oxidative injury by regulating mitochondrial quality control
(Elsevier Ireland, 2018-10)
Heme Oxygenase-1 (HO-1), a stress- responsive enzyme which catalyzes heme degradation into iron, carbon monoxide, and biliverdin, exerts a neuroprotective role involving many different signaling pathways. In Parkinson ...
The effect of nitric oxide on Heme Oxygenase gene expression in soybean leaves
(Springer, 2007-10)
Heme oxygenase (HO, EC 1.14.99.3) catalyzes the oxidative conversion of heme to biliverdin IXalpha with the concomitant release of carbon monoxide and iron. Recently, HO has been involved in the protection against oxidative ...