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Endothelial cell regulation of systemic haemodynamics and metabolism acts through the HIF transcription factors
(2021)
Abstract
Background
The vascular endothelium has important endocrine and paracrine roles, particularly in the regulation of vascular tone and immune function, and it has ...
HIF involvement in the regulation of rat Sertoli cell proliferation by FSH
(Academic Press Inc Elsevier Science, 2018-08)
The final number of Sertoli cells reached during the proliferative periods determines sperm production capacity in adulthood. It is well known that FSH increases the rate of proliferation of Sertoli cells; however, little ...
Caveolin-1-Mediated Tumor Suppression Is Linked to Reduced HIF1α S-Nitrosylation and Transcriptional Activity in Hypoxia
(2020)
Caveolin-1 (CAV1) is a well-established nitric oxide synthase inhibitor, whose function as a tumor suppressor is favored by, but not entirely dependent on, the presence of E-cadherin. Tumors are frequently hypoxic and the ...
Immunohistochemical investigation of the angiogenic proteins VEGF, HIF-1α and CD34 in invasive ductal carcinoma of the breast
(2013-07-29)
The expression of prognostic markers in cancer has become important in diagnostic routine and research. A high mitotic rate compromises the individual cell access to oxygen and nutrients, due to reduced blood supply. Cells ...
Immunohistochemical investigation of the angiogenic proteins VEGF, HIF-1α and CD34 in invasive ductal carcinoma of the breast
(2013-07-29)
The expression of prognostic markers in cancer has become important in diagnostic routine and research. A high mitotic rate compromises the individual cell access to oxygen and nutrients, due to reduced blood supply. Cells ...
Perfil da expressão de HIF-1α em células linfoides do infiltrado inflamatório peritumoral e intratumoral como marcador prognóstico do carcinoma epidermoide de cavidade oral
(2014-02-21)
O complexo transcricional HIF-1 é responsável por controlar a transcrição de mais de 100 genes envolvidos em resposta celular a hipóxia. A subunidade HIF-1α é estabilizada em condições de hipóxia e dimeriza-se com um a ...
HIF-1α is a protective factor in conditional PHD2-βdeficient mice suffering from severe HIF-2-induced excessive erythropoiesis
(Elsevier, 2013)
Erythropoiesis must be tightly balanced to guarantee adequate oxygen delivery to all tissues in the body. This process relies predominantly on the hormone erythropoietin (EPO) and its transcription factor hypoxia inducible ...
La estabilización de HIF-1α induce la expresión de GEFS claves para la activación de RAB5
(Universidad de Chile, 2019)
INTRODUCCIÓN: Estudios previos de nuestro laboratorio evidenciaron que la GTPasa pequeña
Rab5 promueve la adquisición y mantención de características de malignidad tumoral en condiciones
de hipoxia, lo cual pareciera ser ...
A novel HIF-1α/VMP1-Autophagic Pathway Induces Resistance to Photodynamic Therapy in Colon Cancer Cells.
(Royal Society of Chemistry, 2017-08)
Colon cancer is the third most frequent cancer and the fourth most common cause of cancer-related mortality worldwide and the standard therapy is surgical resection plus adjuvant chemotherapy. Photodynamic therapy (PDT) ...
Participation of HIFs in the regulation of Sertoli cell lactate production
(Elsevier France-editions Scientifiques Medicales Elsevier, 2017-01)
Hypoxia Inducible Factors (HIFs) are master regulators of glycolytic metabolism. HIFs consist of a constitutive HIFbeta (HIFβ) subunit and a HIFalpha (HIFα) subunit, whose half-life depends on prolyl-hydroxylases activity. ...