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Differential uPA expression by TGF-β1 in gingival fibroblasts
(2006)
Transforming Growth Factor-β1 (TGF-β1) plays a key role in connective tissue remodeling and inflammation. Under pathological conditions, like periodontal disease, fibroblasts may display an altered response to this growth ...
IGF-1 modulation of rat cardiac fibroblast behavior and gene expression is age-dependent
(TAYLOR & FRANCIS LTD, 2003-05)
The collagenous extracellular matrix (ECM) forms a stress-tolerant network that is essential for proper function of the vertebrate heart. Profound changes have been detected in the interstitial ECM concurrent with developmental ...
Collagen synthesis by human bone marrow fibroblasts
(Birkhäuser-Verlag, 1987)
Collagen synthesis was measured in fibroblast cultures derived from normal and acute lymphoblastic leukemia (ALL) bone marrow. Collagen production was higher in normal than in ALL fibroblasts. These cells elaborate type I ...
Modulation of androgen receptor protein by culture conditions of human skin fibroblasts
(2002)
Cultures of skin fibroblasts show variation of androgen binding with culture conditions; binding variations are usually avoided by using confluent cultures. In this work, we analysed the effect of cell density and mitogenic ...
Differential uPA expression by TGF-beta 1 in gingival fibroblasts
(INT AMER ASSOC DENTAL RESEARCHI A D R/A A D R, 2006-02)
Transforming Growth Factor-beta 1 (TGF-beta 1) plays a key role in connective tissue remodeling and inflammation. Under pathological conditions, like periodontal disease, fibroblasts may display an altered response to this ...
TGF-β1 prevents simulated ischemia/reperfusion-induced cardiac fibroblast apoptosis by activation of both canonical and non-canonical signaling pathways
(2013)
Ischemia/reperfusion injury is a major cause of myocardial death. In the heart, cardiac fibroblasts play a
critical role in healing post myocardial infarction. TGF-β1 has shown cardioprotective effects in cardiac damage; ...
Induction of the myofibroblastic phenotype in human gingival fibroblasts by transforming growth factor-β1: Role of RhoA-ROCK and c-Jun N-terminal kinase signaling pathways
(2006)
Background and Objectives: Myofibroblastic differentiation is an important event in gingival wound healing and chronic inflammation. Transforming frowth factor-β 1 (TGF-β1) is a potent growth factor that has been implicated ...
Increased fibroblast density in actinic cheilitis: association with tryptase-positive mast cells, actinic elastosis and epithelial p53 and COX-2 expression
(John Wiley, 2012)
BACKGROUND: Actinic cheilitis (AC) is characterized
by epithelial and connective tissue alterations caused by
ultraviolet sunlight overexposure known as photodamage.
Fibroblasts have been linked to photodamage and
tumor ...
Induction of the myofibroblastic phenotype in human gingival fibroblasts by transforming growth factor-b1: role of RhoA-ROCK and c-Jun N-terminal kinase signaling pathways
(Blackwell Munksgaard Ltd, 2006-06-05)
Myofibroblastic differentiation is an important event
in gingival wound healing and chronic inflammation. Transforming frowth factorb
1 (TGF-b1) is a potent growth factor that has been implicated in this process.
Gingival ...
Matrix metalloproteinases regulate extracellular levels of SDF-1/CXCL12, IL-6 and VEGF in hydrogen peroxide-stimulated human periodontal ligament fibroblasts
(Elsevier, 2015)
Periodontitis is a highly prevalent infectious disease characterized by the progressive inflammatory
destruction of tooth-supporting structures, leading to tooth loss. The underling molecular mechanisms
of the disease ...