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Actors with Multiple Roles: Pleiotropic Enhancers and the Paradigm of Enhancer Modularity
(Elsevier Science London, 2019-06)
The current paradigm in the field of gene regulation postulates that regulatory information for generating gene expression is organized into modules (enhancers), each containing the information for driving gene expression ...
Comprehensive Analysis of a cis-Regulatory Region Reveals Pleiotropy in Enhancer Function
(Elsevier, 2018-03)
Developmental genes can have complex cis-regulatory regions with multiple enhancers. Early work revealed remarkable modularity of enhancers, whereby distinct DNA regions drive gene expression in defined spatiotemporal ...
The degree of enhancer or promoter activity is reflected by the levels and directionality of eRNA transcription
(Cold Spring Harbor Laboratory Press, 2018-01)
Gene expression is regulated by promoters, which initiate transcription, and enhancers, which control their temporal and spatial activity. However, the discovery that mammalian enhancers also initiate transcription questions ...
Evolution of transcriptional enhancers and animal diversity
(The Royal Society, 2013-12)
Deciphering the genetic bases that drive animal diversity is one of the major challenges of modern biology. Although four decades ago it was proposed that animal evolution was mainly driven by changes in cis-regulatory DNA ...
Metal Enhanced fluorescence emission and Quenching protection effect with a host-guest Nanophotonic-supramolecular structure
(Society of Photo-Optical Instrumentation Engineers, 2018-07)
The functionalization of the nanoparticle's (NP) surface is one method for tuning their overall properties to fit targeted applications. We developed a nanosensor based on the specific supramolecular interactions between ...
Enhancement and confinement analysis of the electromagnetic fields inside hot spots
(American Chemical Society, 2009-04)
A novel and easy approach to implement is developed to analyze the degree of convergence, confinement, and enhancement (Γ) of calculated electromagnetic fields generated in plasmonic nanoparticles (NPs) of arbitrary shape. ...
Feasibility of dose enhancement assessment: Preliminary results by means of Gd-infused polymer gel dosimeter and Monte Carlo study
(Pergamon-Elsevier Science Ltd, 2018-11-11)
This work reports the experimental development of an integral Gd-infused dosimeter suitable for Gd dose enhancement assessment along with Monte Carlo simulations applied to determine the dose enhancement by radioactive and ...
Near-field enhancement of multipole plasmon resonances in Ag and Au nanowires
(American Chemical Society, 2009-04)
In this paper, we investigate theoretically the electromagnetic field enhancement arising from excitation of silver and gold nanowires (NWs) of finite length, capable of sustaining surface plasmon resonances of different ...
Enhancer turnover and conserved regulatory function in vertebrate evolution
(The Royal Society, 2013-12)
Mutations in regulatory regions including enhancers are an important source of variation and innovation during evolution. Enhancers can evolve by changes in the sequence, arrangement and repertoire of transcription factor ...
Integration of Fricke gel dosimetry with Ag nanoparticles for experimental dose enhancement determination in theranostics
(Pergamon-Elsevier Science Ltd, 2018-11-22)
The use and implementation of nanoparticles in medicine has grown exponentially in the last twenty years. Their main applications include drug delivery, theranostics, tissue engineering and magneto function. Dosimetry ...