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Anxiolytic-like effects induced by blockade of transient receptor potential vanilloid type 1 (TRPV1) channels in the medial prefrontal cortex of rats
(SPRINGER, 2009)
The endocannabinoid anandamide, in addition to activating cannabinoid type 1 receptors (CB1), may act as an agonist at transient receptor potential vanilloid type 1 (TRPV1) channels. In the periaqueductal gray, CB1 activation ...
Modulation of anxiety-like behaviour by Transient Receptor Potential Vanilloid Type 1 (TRPV1) channels located in the dorsolateral periaqueductal gray
(ELSEVIER SCIENCE BV, 2009)
The endocannabinoid anandamide is a possible agonist at the Transient Receptor Potential Vanilloid Type 1 (TRPV1) channel, in addition to its agonist activity at cannabinoid type 1 (CB1) receptor. In the midbrain dorsolateral ...
Fine-tuning of defensive behaviors in the dorsal periaqueductal gray by atypical neurotransmitters
(Associação Brasileira de Divulgação Científica, 2012)
This paper presents an up-to-date review of the evidence indicating that atypical neurotransmitters such as nitric oxide (NO) and endocannabinoids (eCBs) play an important role in the regulation of aversive responses in ...
The endocannabinoid and endovanilloid systems interact in the rat prelimbic medial prefrontal cortex to control anxiety-like behavior
(PERGAMON-ELSEVIER SCIENCE LTDOXFORD, 2012)
Cannabinoid receptor 1 (CB1) agonists usually induce dose-dependent biphasic effects on anxiety-related responses. Low doses induce anxiolytic-like effects, whereas high doses are ineffective or anxiogenic, probably due ...
Depression as a Neuroendocrine Disorder: Emerging Neuropsychopharmacological Approaches beyond Monoamines
(Hindawi, 2019)
Depression is currently recognized as a crucial problem in everyday clinical practice, in light of ever-increasing rates of prevalence, as well as disability, morbidity, and mortality related to this disorder. Currently ...
Participação de receptores TRPV1 nas respostas defensivas mediadas pela substância cinzenta periaquedutal dorsolateral de ratos
(Universidade Federal de Minas GeraisUFMG, 2011-10-14)
The behavioral responses of fear and anxiety results from the expression of emotions arising from the animal reactions in the face of aversive stimuli they present a danger or threat to survival. Such responses are related ...
Blockade of Cannabinoid CB1 Receptors in the Dorsal Periaqueductal Gray Unmasks the Antinociceptive Effect of Local Injections of Anandamide in Mice
(Frontiers Media Sa, 2017-10-04)
Divergent results in pain management account for the growing number of studies aiming at elucidating the pharmacology of the endocannabinoid/endovanilloid anandamide (AEA) within several pain-related brain structures. For ...
Papel da Anandamida na modulação supraespinal da nocicepção e da antinocicepção induzida pelo estresse de derrota social
(Universidade Federal de São CarlosUFSCarPrograma Interinstitucional de Pós-Graduação em Ciências Fisiológicas - PIPGCFCâmpus São Carlos, 2017-09-22)
Anandamide (AEA), initially considered an endocannabinoid, has recently been described as a vanilloid agonist capable of modulating acute pain in brain regions such as the periaqueductal gray (PAG). In this context, AEA ...
Aspectos biomédicos de las fosfolipasas A2 en la especie humana
(Universidad Autónoma de Bucaramanga UNABFacultad Ciencias de la SaludPregrado Medicina, 2008-04-11)
Las fosfolipasas son un grupo ubicuo y diverso de enzimas, descritas desde 1967, que inducen cambios en la composición membranal, activan la cascada inflamatoria y alteran las vías de señalización celular. Las fosfolipasas ...
Fosfolipasas A2: Grandes familias y mecanismos de acción
(Sociedad de Cirugía de Bogotá, Hospital de San José y Fundación Universitaria de Ciencias de la Salud, 2009-12-01)