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The contribution of TRPC1, TRPC3, TRPC5 and TRPC6 to touch and hearing
(Elsevier Ireland, 2016-01)
Transient receptor potential channels have diverse roles in mechanosensation. Evidence is accumulating that members of the canonical subfamily of TRP channels (TRPC) are involved in touch and hearing. Characteristic features ...
Heightened seizure severity in somatostatin knockout mice
(Elsevier Science, 2002-01)
Patients and experimental models of temporal lobe epilepsy display loss of somatostatinergic neurons in the dentate gyrus. To determine if loss of the peptide somatostatin contributes to epileptic seizures we examined ...
Peroxisome proliferator receptor gamma and the control of glucose metabolism: insights from knockout mice
(Elsevier, 2019)
Peroxisome proliferator receptor gamma (PPARγ) is a nuclear receptor first identified for its role in adipose tissue differentiation. Two PPARγ isoforms were identified that differed at the amino terminus with the PPARγ2 ...
Acute behavioural responses to nicotine and nicotine withdrawal syndrome are modified in GABAB1 knockout mice
(Pergamon-Elsevier Science Ltd, 2012-10)
Nicotine is the main active component of tobacco, and has both acute and chronic pharmacological effects that can contribute to its abuse potential in humans. The aim of the present study was to evaluate a possible role ...
Lack of operant ethanol self-administration in dopamine D2 receptor knockout mice
(Springer, 2000-10)
Rationale: Dopamine D2 receptors are postulated to play an important role in modulating the reinforcing effects of abused drugs including ethanol. Objectives: This experiment examined operant ethanol self-administration ...
GH modulates hepatic epidermal growth factor signaling in the mouse.
(BioScientifica, 2010-03)
Epidermal growth factor (EGF) is a key regulator of cell survival and proliferation involved in the pathogenesis and progression of different types of cancer. The EGF receptor (EGFR) is activated by binding of the specific ...
Reward-seeking and discrimination deficits displayed by hypodopaminergic mice are prevented in mice lacking dopamine D4 receptors
(Wiley-liss, Div John Wiley & Sons Inc, 2009-11)
The dopamine D4 receptor (D4R) is predominantly expressed in the prefrontal cortex, a brain area that integrates motor, rewarding, and cognitive information. Because participation of D4Rs in executive learning is largely ...
Failure of Intravenous Morphine to Serve as an Effective Instrumental Reinforcer in Dopamine D2 Receptor Knock-Out Mice
(Society for Neuroscience, 2002-05)
The rewarding effects of opiates are thought to be mediated through dopaminergic mechanisms in the ventral tegmental area, dopamine-independent mechanisms in the nucleus accumbens, or both. The purpose of the present study ...
Adrenergic and Endothelin B Receptor-Dependent Hypertension in Dopamine Receptor Type-2 Knockout Mice
(Lippincott Williams, 2001-09)
Polymorphism of the dopamine receptor type-2 (D2) gene is associated with essential hypertension. To assess whether D2 receptors participate in regulation of blood pressure (BP), we studied mice in which the D2 receptor ...
Role of dopamine D1-like receptors in methamphetamine locomotor responses of D2 receptor knockout mice
(Wiley Blackwell Publishing, Inc, 2008-07)
Behavioral sensitization to psychostimulants manifests as an increased locomotor response with repeated administration. Dopamine systems are accepted to play a fundamental role in sensitization, but the role of specific ...