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Brain-to-Plasma Concentration Ratio and Unbound Partition Coefficient
(Springer Nature Switzerland AG, 2021)
The brain-to-plasma concentration ratio (or totalbrain-to-plasma ratio, or simply, brain-to-plasma ratio, Kp, also referred toas B/P ratio or BB) is, as suggested by the name, the ratio between the total(bound and unbound) ...
Enhanced intestinal permeability and oral bioavailability of enalapril maleate upon complexation with the cationic polymethacrylate Eudragit E100
(Elsevier Science, 2014-05)
The low bioavailability of enalapril maleate associated to its instability in solid state motivated the development of a polyelectrolyte-drug complex between enalapril maleate and the cationic polymethacrylate Eudragit ...
Polymer-based carriers for opthalmic drug delivery
(Elsevier Science, 2018-09)
Despite the wide range of diseases affecting the eye, ocular bioavailability remains a challenge in ophthalmic drug delivery. Nowadays an extensive variety of polymers are being explored to develop colloidal drug carriers ...
The use of saliva as a biological fluid in relative bioavailability studies: Comparison and correlation with plasma results
(John Wiley & Sons Ltd, 2010-11)
The aim of the present study was to present new evidence supporting the use of saliva as a biological fluid in relative bioavailability studies. Carbamazepine was chosen as a model drug because of its suitability for ...
Solid dispersion technology as a strategy to improve the bioavailability of poorly soluble drugs
(Future Medicine, 2019-05)
Over the last half-century, solid dispersions (SDs) have been intensively investigated as a strategy to improve drugs solubility and dissolution rate, enhancing oral bioavailability. In this review, an overview of the state ...
Routes of Drug Administration
(Springer International Publishing, 2019)
Systemic absorption of a drug depends on its physicochemical properties, the nature of the dosage form on which it is included and the anatomical and physiological characteristics of the site of absorption. These considerations ...
Potential interactions between an oral fosfomycin formulation and feed or drinking water: Impact on bioavailability in piglets
(Wiley Blackwell Publishing, Inc, 2021-03)
Feed and drinking water are the most frequently used vehicles for administration of antibiotics in intensive pig production. Interactions of drugs with feed and water components may affect dissolution and bioavailability. ...
Impact of water hardness on oxytetracycline oral bioavailability in fed and fasted piglets
(Wiley Blackwell Publishing, Inc, 2019-07)
Water hardness is a critical factor that affects oxytetracycline dissolution by chelation with cations. These interactions may lead to impaired dosing and consequently decrease absorption. Moreover, feed present in ...
Effect of genotype and sex of the host on the bioavailability of novel albendazole microcrystals based on chitosan and cellulose derivatives
(Springer, 2020-05)
Albendazole (ABZ), an anthelmintic compound widely used in the treatment of systemic nematode infections, is included in the list of class II drugs based on the Biopharmaceutical Classification System. ABZ has limited ...
Liposomes containing cyclodextrins or meglumine to solubilize and improve the bioavailability of poorly soluble drugs
(Elsevier Science, 2017-03-19)
Poorly soluble drug-loaded liposomes are well known for their ability to solubilize and improve the bioavailability of the carried molecules, and may provide benefits as oral drug delivery systems. In this work, we aim to ...