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Combined therapy for alzheimer’s disease: Tacrine and PAMAM dendrimers co-administration reduces the side effects of the drug without modifying its activity
(Springer, 2020-03-25)
Alzheimer´s disease has become a public health priority, so an investigation of new therapies is required. Tacrine (TAC) was licensed for treatments; however, its oral administration caused hepatotoxicity, so it is essential ...
Alternative treatment of fungal infections: Synergy with non-antifungal agents
(Wiley Blackwell Publishing, Inc, 2021-03)
Fungal infections are responsible for high mortality rates in immunocompromised and high-risk surgical patients. Therapy failures during the last decades due to increasing multidrug resistance demand innovative strategies ...
Combined therapy with Benznidazole and repurposed drugs Clofazimine and Benidipine for chronic Chagas disease
(Elsevier France-editions Scientifiques Medicales Elsevier, 2019-10)
Current treatment for Chagas disease is limited to Benznidazole andNifurtimox which present side effects and limited efficacy at the chronicstage of disease. This underscores the need for novel therapeuticapproaches ...
Combination antifungal therapy: A strategy for the management of invasive fungal infections
(Grupo Ars Xxi Comunicacion S L, 2014-09)
The lack of an ideal antifungal drug or completely successful agent, suggests that combination therapy may be an appropriate option for the management of fungal infections. In this review, different antifungal combination ...
Combined chemotherapy and ALA-based photodynamic therapy in leukemic murine cells
(Pergamon-Elsevier Science Ltd, 2012-09)
The effects of combined administration of doxorubicin (DOX) and vincristine (VCR), with 5-aminolevulinic acid photodynamic treatment (ALA-PDT), were analyzed in sensitive murine leukemic cell lines (LBR-) and DOX and VCR ...
Stimulus responsive nanogels for drug delivery
(Elsevier, 2018)
Nanogels have attracted growing interest in the last five decades owing to their potential for biomedical applications, including drug delivery systems and bioimaging. They are able to encapsulate highly amounts of ...
Role of antifungal combinations in difficult to treat candida infections
(Multidisciplinary Digital Publishing Institute, 2021-09)
Candida infections are varied and, depending on the immune status of the patient, a life-threatening form may develop. C. albicans is the most prevalent species isolated, however, a significant shift towards other Candida ...
Exploring Protein-Protein Interactions as Drug Targets for Anti-cancer Therapy with In Silico Workflows
(Humana Press, 2017)
We describe a computational protocol to aid the design of small molecule and peptide drugs that target protein-protein interactions, particularly for anti-cancer therapy. To achieve this goal, we explore multiple strategies, ...
Antifungal activity of traditional medicinal plants from Argentina: effect of their combination with antifungal drugs
(Bentham Science Publishers, 2019-02)
The incidence of fungal infections has experienced a marked increase in the last two decades being limited to a few drugs with serious drawbacks. Combination therapy has emerged as an approach to improve the efficacy of ...