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Diabetic cardiomyopathy and metabolic remodeling of the heart
(2013)
The incidence and prevalence of diabetes mellitus are both increasing rapidly in societies around the globe.
The majority of patients with diabetes succumb ultimately to heart disease, much of which stems from
atherosclerotic ...
Maintaining Myocardial Glucose Utilization in Diabetic Cardiomyopathy Accelerates Mitochondrial Dysfunction
(American Diabetes Association, 2020)
Cardiac glucose uptake and oxidation are reduced in diabetes despite hyperglycemia. Mitochondrial dysfunction contributes to heart failure in diabetes. It is unclear whether these changes are adaptive or maladaptive. To ...
Quercetin prevents diastolic dysfunction induced by a high-cholesterol diet: role of oxidative stress and bioenergetics in hyperglycemic rats
(Hindawi Ltd, 2018)
Alterations in cardiac energy metabolism play a key role in the pathogenesis of diabetic cardiomyopathy. Hypercholesterolemia associated with bioenergetic impairment and oxidative stress has not been well characterized in ...
Emerging role of mitophagy in cardiovascular physiology and pathology
(Elsevier, 2020)
Healthy mitochondrial function is imperative for most tissues, but especially those with a high energy demand. Robust evidence linking mitochondrial dysfunction with cardiovascular disease has demonstrated that mitochondrial ...
New Molecular Insights of Insulin in Diabetic Cardiomyopathy
(Frontiers Media S.A., 2016-04)
Type 2 diabetes mellitus (T2DM) is a highly prevalent disease worldwide. Cardiovascular disorders generated as a consequence of T2DM are a major cause of death related to this disease. Diabetic cardiomyopathy (DCM) is ...
Clinical and gated SPECT MPI parameters associated with super-response to cardiac resynchronization therapy
(Springer, 2020)
Purpose We sought to evaluate the behavior of cardiac mechanical synchrony as measured by phase SD (PSD) derived from gated MPI SPECT (gSPECT) in patients with super-response after CRT and to evaluate the clinical and ...
Preserved Ca2+ handling and excitation-contraction coupling in muscle fibres from diet-induced obese mice
(Springer, 2020)
Aims/hypothesis Disrupted intracellular Ca2+ handling is known to play a role in diabetic cardiomyopathy but it has also been
postulated to contribute to obesity- and type 2 diabetes-associated skeletal muscle dysfunction. ...
Redistribution of heart failure as the cause of death: the Atherosclerosis Risk in Communities Study
(BioMed Central, 2014)
Background: Heart failure is sometimes incorrectly listed as the underlying cause of death (UCD) on death certificates,
thus compromising the accuracy and comparability of mortality statistics. Statistical redistribution ...
Role of FoxO3a as a negative regulator of the cardiac myofibroblast conversion induced by TGF-β1
(Elsevier, 2020)
Cardiac fibroblasts (CFs) are necessary to maintain extracellular matrix (ECM) homeostasis in the heart. Normally, CFs are quiescent and secrete small amounts of ECM components, whereas, in pathological conditions, they ...
Mitochondrial dynamics, mitophagy and cardiovascular disease
(WILEY-BLACKWELL, 2016)
Cardiac hypertrophy is often initiated as an adaptive response to haemodynamic stress or myocardial injury, and allows the heart to meet an increased demand for oxygen. Although initially beneficial, hypertrophy can ...