Buscar
Mostrando ítems 1-10 de 18
Cotinine Plus Krill Oil Decreased Depressive Behavior, and Increased Astrocytes Survival in the Hippocampus of Mice Subjected to Restraint Stress
(2018)
Restraint stress (RS) is a condition affecting millions of people worldwide. The investigation of new therapies to alleviate the consequences of prolonged RS is much needed. Cotinine, a nicotine-derivative, has shown to ...
Intranasal cotinine improves memory and reduces depressive-like behavior, and GFAP+ cells loss induced by restraint stress in mice.
(2017)
Posttraumatic stress disorder (PTSD), chronic psychological stress, and major depressive disorder have been found to be associated with a significant decrease in glial fibrillary acidic protein (GFAP) immunoreactivity in ...
Is vegf a key target of cotinine and other potential therapies against alzheimer disease?
(2017)
Background: The vascular endothelial growth factor (VEGF) is a neuroprotective cytokine that promotes neurogenesis and angiogenesis in the brain. In animal models, it has been shown that environmental enrichment and exercise, ...
Intranasal cotinine plus krill oil facilitates fear extinction, decreases depressive-like behavior, and increases hippocampal calcineurin a levels in mice (vol 55, pg 7949, 2018)
(2018)
Failure in fear extinction is one of the more troublesome characteristics of posttraumatic stress disorder (PTSD). Cotinine facilitates fear memory extinction and reduces depressive-like behavior when administered 24 h ...
Cotinine Improves Visual Recognition Memory And Decreases Cortical Tau Phosphorylation In The Tg6799 Mice
(2017)
Alzheimer's disease (AD) is associated with the progressive aggregation of hyperphosphorylated forms of the microtubule associated protein Tau in the central nervous system. Cotinine, the main metabolite of nicotine, reduced ...
Post-treatment with cotinine improved memory and decreased depressive-like behavior after chemotherapy in rats
(2016)
Most cancer patients treated with systemic adjuvant chemotherapy endure long-lasting side effects including decrease in concentration, forgetfulness and slower thinking, which are globally termed "chemobrain." Cotinine, ...