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Loss of cardiac carnitine palmitoyltransferase 2 results in rapamycin-resistant, acetylation-independent hypertrophy
(American Society for Biochemistry and Molecular Biology, 2017-11)
Cardiac hypertrophy is closely linked to impaired fatty acid oxidation, but the molecular basis of this link is unclear. Here, we investigated the loss of an obligate enzyme in mitochondrial long-chain fatty acid oxidation, ...
Reduced sarcolemmal expression and function of the NBCe1 isoform of the Na+–HCO3− cotransporter in hypertrophied cardiomyocytes of spontaneously hypertensive rats: role of the renin–angiotensin system
(Oxford University Press, 2014-02)
Aims Electroneutral (NBCn1) and electrogenic (NBCe1) isoforms of the Na+–HCO3− cotransporter (NBC) coexist in the heart. We studied the expression and function of these isoforms in hearts of Wistar and spontaneously ...
Angiotensin II requires an intact cardiac Thyrotropin-Releasing Hormone (TRH) system to Induce cardiac hypertrophy in mouse
(Academic Press Ltd - Elsevier Science Ltd, 2018-11)
Cardiac tyhrotropin-releasing hormone (TRH) is overexpressed in the hypertrophied left ventricle (LV) of spontaneously hypertensive rats (SHR) and its inhibition prevents both hypertrophy and fibrosis. In a normal heart, ...
Regulation of the Cardiac Sodium/Bicarbonate cotransporter by Angiotensin II: potential contribution to structural, ionic and electrophysiological Myocardial remodelling
(Bentham Science Publishers, 2013-02)
The sodium/ bicarbonate cotransporter (NBC) is, with the Na+ /H+ exchanger (NHE), an important alkalinizing mechanism that maintains cellular intracellular pH (pHi). In the heart exists at least three isoforms of NBC, one ...
The activation of the G protein-coupled estrogen receptor (GPER) prevents and regresses cardiac hypertrophy
(Elsevier Inc, 2020-02-01)
Ventricular hypertrophy is a risk factors for arrhythmias, ischemia and sudden death. It involves cellular modifications leading to a pathological remodeling and is associated with heart failure. The activation of the G ...
Cardiac Thyrotropin-releasing Hormone Inhibition Improves Ventricular Function and Reduces Hypertrophy and Fibrosis After Myocardial Infarction in Rats
(Churchill Livingstone Inc Medical Publishers, 2021-07)
Background: Cardiac thyrotropin-releasing hormone (TRH) is a tripeptide with still unknown functions. We demonstrated that the left ventricle (LV) TRH system is hyperactivated in spontaneously hypertensive rats and its ...
The Role of Natriuretic peptides in Renovascular Hypertension and its correlation with the Evolution of Myocardial Hypertrophy
(Sociedad Argentina de Cardiología, 2010-08)
The interactions between pressure and volume overload that occur in hypertension lead to different patterns of cardiac hypertrophy and to increase in natriuretic peptides (NPs). The profiles of atrial natriuretic peptide ...
Physiological cardiac hypertrophy: Critical role of AKT in the prevention of NHE-1 hyperactivity
(Elsevier, 2014-09)
Background: The involvement of NHE-1 hyperactivity, critical for pathological cardiac hypertrophy (CH), in physiological CH has not been elucidated yet. Stimulation of NHE-1 increases intracellular Na+ and Ca2 + favouring ...
Chasing cardiac physiology and pathology down the CaMKII cascade
(American Physiological Society, 2015-02)
Calcium dynamics is central in cardiac physiology, as the key event leading to the excitation-contraction coupling (ECC) and relaxation processes. The primary function of Ca2+ in the heart is the control of mechanical ...