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A novel α-conotoxin, PeIA, cloned from Conus pergrandis, discriminates between Rat α9α10 and α7 nicotinic cholinergic receptors
(American Society for Biochemistry and Molecular Biology, 2005-08)
The α9 and α10 nicotinic cholinergic subunits assemble to form the receptor believed to mediate synaptic transmission between efferent olivocochlear fibers and hair cells of the cochlea, one of the few examples of postsynaptic ...
Ric-3 chaperone-mediated stable cell-surface expression of the neuronal α7 nicotinic acetylcholine receptor in mammalian cells
(Nature Publishing Group, 2009-06)
Aim: Studies of the α7-type neuronal nicotinic acetylcholine receptor (AChR), one of the receptor forms involved in many physiologically relevant processes in the central nervous system, have been hampered by the inability ...
Unravelling the molecular players at the cholinergic efferent synapse of the zebrafish lateral line
(Society for Neuroscience, 2020-11)
The lateral line (LL) is a sensory system that allows fish and amphibians to detect water currents. LL responsiveness is modulated by efferent neurons which aid to distinguish between external and self-generated stimuli, ...
Relationship between α7 nAChR and apoptosis in human lymphocytes
(Elsevier Science, 2005-03)
The presence of nicotinic receptors (nAChRs) in blood cells has been demonstrated. However, little is known about their functional roles. We have detected mRNA of a7 nAChR in peripheral human lymphocytes and determined ...
A deep learning-based approach to model anomalous diffusion of membrane proteins: The case of the nicotinic acetylcholine receptor
(Oxford University Press, 2021-10)
We present a concatenated deep-learning multiple neural network system for the analysis of single-molecule trajectories. We apply this machine learning-based analysis to characterize the translational diffusion of the ...
A novel pharmacological activity of caffeine in the cholinergic system
(Pergamon-Elsevier Science Ltd, 2018-06)
Cholinergic deficit is regarded as an important factor responsible for Alzheimer's disease (AD) symptoms. Acetylcholinesterase (AChE) and nicotinic receptor (AChR) are two molecular targets for the treatment of this disease. ...
Antibody-induced acetylcholine receptor clusters inhabit liquid-ordered and liquid-disordered domains
(Elsevier, 2013-10)
The distribution of nicotinic acetylcholine receptor (AChR) clusters at the cell membrane was studied in CHO-K1/A5 cells using fluorescence microscopy. Di-4-ANEPPDHQ, a fluorescent probe that differentiates between ...
A new tool to sense pH changes at the neuromuscular junction synaptic cleft
(Nature, 2020-11-24)
Synaptic transmission triggers transient acidification of the synaptic cleft. Recently, it has been shown that pH affects the opening of postsynaptic channels and therefore the production of tools that allow to study these ...
Interaction of Bupropion with Muscle-Type Nicotinic Acetylcholine Receptors in Different Conformational States
(American Chemical Society, 2009-06-30)
To characterize the binding sites and the mechanisms of inhibition of bupropion on muscle-type nicotinic acetylcholine receptors (AChRs), structural and functional approaches were used. The results established that bupropion: ...
The Nemertine Toxin Anabaseine and Its Derivative DMXBA (GTS-21): Chemical and Pharmacological Properties
(Molecular Diversity Preservation International, 2006-04)
Nemertines are a phylum of carnivorous marine worms that possess a variety of alkaloidal, peptidic or proteinaceous toxins that serve as chemical defenses against potential predators. The hoplonemertines additionally ...