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Issues in drug metabolism of major antihypertensive drugs: β-blockers, calcium channel antagonists and angiotensin receptor blockers
(Taylor & Francis, 2010-01)
Several first-line antihypertensive drugs, including calcium channel blockers, beta-adrenergic blockers and angiotensin receptor blockers, undergo metabolism through different CYP isoforms. As a consequence of CYP-dependent ...
Factors influencing hepatic metabolism of antihypertensive drugs: impact on clinical response
(Informa Healthcare, 2019-01)
Introduction: Although main antihypertensive drugs are able to efficiently reduce blood pressure, only a third of treated hypertensive patients achieve optimal blood pressure control. Extensive interpatient variability on ...
A comparison of the effects of the selective peripheral α1-blocker terazosin with the selective β1-blocker atenolol on blood pressure, exercise performance and the lipid profile in mild-to-moderate essential hypertension
(Springer-Verlag, 1992)
The effects of six weeks of treatment with the selective peripheral α1-adrenoceptor blocker terazosin, or the selective β1-adrenoceptor blocker atenolol on blood pressure, exercise performance and blood lipid profile were ...
Models for evaluating the pharmacokinetics and pharmacodynamics for β-blockers
(Informa Healthcare, 2014-04)
Introduction: β-blocker therapy plays an important role in the treatment of various diseases, including hypertension, myocardial infarction and heart failure. Although all β-blockers shared their ability to competitively ...
Effect of β-blockers on the risk of atrial fibrillation in patients with acute myocardial infarction
(Faculdade de Medicina / USP, 2010)
INTRODUCTION: Oral β-blockers improve the prognosis of patients with acute myocardial infarction, while atrial fibrillation worsens the prognosis of this population. The reduction of atrial fibrillation incidence in ...
A Method for Dimensioning and Designing the Zero-Sequence Electromagnetic Blocker Considering System Unbalance Factor
(Ieee-inst Electrical Electronics Engineers Inc, 2020-08-01)
The zero-sequence electromagnetic suppressor (ZSES) refers to a well-established alternative during the zero-sequence current mitigation in industrial systems. Its arrangement consists of a zero-sequence electromagnetic ...
Benzenesulfonamides act as open-channel blockers on K V 3.1 potassium channel
(2019-02-07)
K V 3.1 blockers can serve as modulators of the rate of action potential firing in neurons with high rates of firing such as those of the auditory system. We studied the effects of several bioisosteres of N-alkylbenzenes ...
Acute effects of third generation β-blockers on short-term and beat-to-beat blood pressure variability in sinoaortic-denervated rats
(Nature Publishing Group, 2013-04)
An increase in blood pressure variability (BPV) contributes to the development of target organ damage associated with hypertension. Treatment with conventional b-blockers, such as atenolol, has been associated with an ...
Calcium channel blockers are independently associated with short sleep duration in hypertensive patients with obstructive sleep apnea
(LIPPINCOTT WILLIAMS & WILKINS, 2011)
Objective Obstructive sleep apnea (OSA) and hypertension (HYP) frequently coexist and have additive harmful effects on the cardiovascular system. There is also growing evidence that short sleep duration may contribute ...