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Involvement of glutamate in retinal protection against ischemia/reperfusion damage induced by post-conditioning.
(Wiley Blackwell Publishing, Inc, 2009-12)
Retinal ischemia could provoke blindness and there is no effective treatment against retinal ischemic damage. Brief intermittent ischemia applied during the onset of reperfusion (i.e., postconditioning) protects the retina ...
The “Use It or Lose It” Dogma in the Retina: Visual Stimulation Promotes Protection Against Retinal Ischemia
(Humana Press, 2019-08)
Enriched environment (EE) protects the retina from adult rats against ischemia/reperfusion (I/R) injury; however, how the components of EE contribute to the recovery after retinal ischemic damage remains unclear. We analyzed ...
Gαi2 - and Gαi3-deficient mice display opposite severity of myocardial ischemia reperfusion injury
(Public Library of Science, 2014-05)
G-protein-coupled receptors (GPCRs) are the most abundant receptors in the heart and therefore are common targets for cardiovascular therapeutics. The activated GPCRs transduce their signals via heterotrimeric G-proteins. ...
Effects of wortmannin on cardioprotection exerted by ischemic preconditioning in rat hearts subjected to ischemia-reperfusion
(Servicio Publicaciones Universidad Navarra, 2016-03)
Ischemic preconditioning (IPC) is one of the most powerful interventions to reduce ischemia-reperfusion injury. The aim of the present study was to investigate the involvement of the phosphatidylinositol-3-kinases (PI3Ks) ...
Radiographic and symptomatic brain ischemia in CEA and CAS: A systematic review and meta-analysis
(American Academic of Neurology, 2017-10-11)
OBJECTIVE: In a systematic review, we compared ratio of new periprocedural radiographic brain ischemia (RBI) to the number of strokes and TIAs among patients undergoing carotid endarterectomy (CEA) and carotid artery ...
Galactomannan as a potential modulator of intestinal ischemia–reperfusion injury
(Academic Press Inc Elsevier Science, 2020-05-01)
Background: Galactomannan (GAL), a polysaccharide present on the cell wall of several fungi, has shown an ability to modulate inflammatory responses through the dectin-1 receptor in human macrophages. However, studies ...
High cholesterol diet effects on ischemia- reperfusion injury of the heart
(National Research Council Canada-NRC Research Press, 2012-09)
Ischemic heart disease is the leading cause of morbi-mortality in developed countries. Both ischemia-reperfusion injury and mechanisms of cardioprotection have been studied for more than 50 years. It is known that the ...
A novel electrophysiologic effect of melatonin on ischemia/reperfusion- induced arrhythmias in isolated rat hearts
(Wiley Blackwell Publishing, Inc, 2009-03)
Reperfusion after a short period of cardiac ischemia triggers ventricular arrhythmias attributable to ionic imbalance and oxidative stress. Melatonin offers some degree of protection, but its effects on the cardiac action ...
Acute treatment with copoazú fermented extract ameliorates myocardial ischemia-reperfusion injury via eNOS activation
(Elsevier Ltd, 2017-07)
Our aim was to examine the effects of aqueous extracts of fermented (CFE) and non-fermented (CNFE) ¨copoazú¨ (fruit of Theobroma grandiflorum) seeds against ischemia-reperfusion injury. Isolated rat hearts were submitted ...
Thioredoxin 1 Plays a Protective Role in Retinas Exposed to Perinatal Hypoxia–Ischemia
(Pergamon-Elsevier Science Ltd, 2019-11)
Thioredoxin family proteins are key modulators of cellular redox regulation and have been linked to several physiological functions, including the cellular response to hypoxia–ischemia. During perinatal hypoxia–ischemia ...