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The dwarf mutation decreases high dose insulin responses in skeletal muscle, the opposite of effects in liver
(Elsevier Ireland, 2003-07)
The in vivo status of the proximal components of the insulin signaling system was investigated in skeletal muscle of Ames (Prop1 df/Prop1df) dwarf mice. The insulin-stimulated phosphorylation of the insulin receptor (IR) ...
Type B Insulin Resistance in Peru
(Elsevier, 2016)
Type B insulin resistance (IR) is a rare autoimmune disease characterized by the presence of insulin receptor autoantibodies, resulting in a marked IR inducing hyperglycemia. Our first case is a 42-year-old female with a ...
Use of cross-reactivity immunoassay to orient insulin replacement in diabetic patients with high levels of insulin antibodies
(Elsevier Science, 2016-10)
The prevalence and high levels of anti-insulin antibodies (IA) have frequently been associated with brittle diabetes, lipodystrophy in the areas where the insulin is injected and/or poor metabolic control. When this happens ...
Insulin and insulin like growth factor II endocytosis and signaling via insulin receptor B
(Biomed Central, 2013-03-11)
Insulin and insulin-like growth factors (IGFs) act on tetrameric tyrosine kinase receptors controlling essential functions including growth, metabolism, reproduction and longevity. The insulin receptor (IR) binds insulin ...
Islet adaptive changes to fructose-induced insulin resistance: β-cell mass, glucokinase, glucose metabolism, and insulin secretion
(BioScientifica, 2009-02)
β-Cell mass, hexokinase/glucokinase (HK/GK) activity, glucose metabolism and insulin secretion were studied in the islets of rats with fructose-induced insulin resistance (IR). Normal male Wistar rats were fed a standard ...
Reduced insulin sensitivity as a marker for acute mountain sickness?
(Mary Ann Liebert, 2013)
The diabetogenic side effects of dexamethasone should therefore be considered for AMS treatment. To examine whether reduced insulin sensitivity is predictive of AMS and how it is affected by dexamethasone at high altitude, ...
Interval Simulator of the Glucose-Insulin System
(Springer, 2019-10)
In this paper, an interval simulator that considers different sources of uncertainty to estimate the blood glucose level of type 1 diabetes patients is presented. In particular, this study examines a model that includes ...
Insulin receptor membrane retention by a traceable chimeric mutant
(Biomed Central, 2013-06)
Background: The insulin receptor (IR) regulates glucose homeostasis, cell growth and differentiation. It has been hypothesized that the specific signaling characteristics of IR are in part determined by ligand-receptor ...
Differential endocytosis and signaling dynamics of insulin receptor variants IR-A and IR-B
(Company of Biologists, 2011-03)
Insulin signaling comprises a complex cascade of events, playing a key role in the regulation of glucose metabolism and cellular growth. Impaired response to insulin is the hallmark of diabetes, whereas upregulated insulin ...
Changes in islet plasma membrane calcium-ATPase activity and isoform expression induced by insulin resistance
(Elsevier Science Inc, 2009-10)
We studied the effect of insulin resistance (IR) induced by administration of a fructose-rich diet (FRD) to normal Wistar rats for 21 days, upon islet plasma membrane calcium ATPases (PMCAs) and insulin secretion. FRD rats ...