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Pharmacokinetic properties and in silico ADME modeling in drug discovery
(Bentham ScienceBussum, 2013-03)
The discovery and development of a new drug are time-consuming, difficult and expensive. This complex process has evolved from classical methods into an integration of modern technologies and innovative strategies addressed ...
pkCSM: Predicting small-molecule pharmacokinetic and toxicity properties using graph-based signatures
(American Chemical Society, 2016)
Farmacocinética de medicamentos de uso pediátrico, visión actual
(2008)
Pharmacokinetics corresponds to the branch of pharmacology that studies the absorption, distribution,
biotransformation and excretion of drugs in the body, in order to proportionate a reference line for
interpretation ...
Effect of ANITVNITV peptide fusion on the bioactivity and pharmacokinetics of human IFN-α2b and a hyper-N-glycosylated variant
(Elsevier Science, 2019-09)
Different strategies have been developed and successfully applied to biotherapeutics in order to improve their in vivo efficacy. The genetic fusion to natural or synthetic glycosylated peptides constitutes a promising ...
A Pharmacokinetic Comparison of Meloxicam and Ketoprofen following Oral Administration to Healthy Dogs
(Springer, 2004-07)
Ketoprofen (KTP) and meloxicam (MLX) are non-steroidal anti-inflamatory drugs used extensively in veterinary medicine. The pharmacokinetics of these drugs were studied in eight dogs following a single oral dose of 1 mg/kg ...
An Introduction to Pharmacokinetics From Conventional to Advanced Systemic Drug Delivery Systems
(CRC Press - Taylor & Francis Group, 2017)
In order to comprehend the peculiarities of advanced drug delivery (nano)system pharmacokinetics, we should first briefly discuss some general aspects of conventional drug delivery systems. This chapter focuses on systemic ...
Assessment of an anti-ageing structured cosmetic formulation containing goji berry
(2019-01-01)
Based on previous studies, it has been found that goji berry (GB), popularly known as a ‘miracle fruit’, has excellent antioxidant potential and can be used in the treatment of skin disorders associated with ageing. This ...
Preclinical studies on the pharmacokinetics, safety, and toxicology of oxfendazole: toward first in human studies
(SAGE Publications, 2015)
A 2-week study in rats identified target organs of oxfendazole toxicity to be bone marrow, epididymis, liver, spleen, testis, and thymus. Female rats had greater oxfendazole exposure and exhibited toxicities at lower doses ...