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Bj-PRO-5a, a natural angiotensin-converting enzyme inhibitor, promotes vasodilatation mediated by both bradykinin B(2) and M1 muscarinic acetylcholine receptors
(PERGAMON-ELSEVIER SCIENCE LTD, 2011)
Bradykinin-potentiating peptides (BPPs) or proline-rich oligopeptides (PROs) isolated from the venom glands of Bothrops jararaca (Bj) were the first natural inhibitors of the angiotensin-converting enzyme (ACE) described. ...
Calcitonin modifies ligand binding to muscarinic receptor in CNS membranes
(Elsevier Science, 2000-03)
Calcitonin (CT) is a peptide produced by the thyroid gland, whose best described role is to prevent bone reabsorption, though it also participates in other biological functions through both central and peripheral mechanisms. ...
Inflammation triggers constitutive activity and agonist-induced negative responses at M(3) muscarinic receptor in dental pulp
(Elsevier Science Inc, 2011-02)
The purpose of this study was to investigate whether the inflammation of rat dental pulp induces the muscarinic acetylcholine receptor (mAChR) constitutive receptor activity. Pulpitis was induced with bacterial lipolysaccharide ...
Muscarinic activation enhances the anti-proliferative effect of paclitaxel in murine breast tumor cells
(Bentham Science Publishers, 2013-10)
Muscarinic acetylcholine receptors (mAChR) are expressed in cells without nervous origin. mAChR are up-regulated in tumor cells and their stimulation can modulate tumor growth. In this work we investigated the ability of ...
Effect of estrogen on intracellular signaling pathways linked to activation of M-2- and M-3-muscarinic acetylcholine receptors in the rat myometrium
(Elsevier B.V., 2000-02-25)
The estrogen treatment of adult female rats induces an increase in myometrium sensitivity to cholinergic agonists and in this tissue the presence of M-2- and M-3-muscarinic acetylcholine (mACh) receptor was shown. We now ...
Impairment of agonist-induced M2 muscarinic receptor activation by autoantibodies from chagasic patients with cardiovascular dysautonomia
(Academic Press Inc Elsevier Science, 2020-03)
Previous studies showed that circulating autoantibodies against M2 muscarinic receptors (anti-M2R Ab) are associated with decreased cardiac parasympathetic modulation in patients with chronic Chagas disease (CD). Here we ...
Participation of non-neuronal muscarinic receptors in the effect of carbachol with paclitaxel on human breast adenocarcinoma cells. Roles of nitric oxide synthase and arginase
(Elsevier Science, 2015-11)
Breast cancer is the most common type of cancer in women and represents a major issue in public health. The most frequent methods to treat these tumors are surgery and/or chemotherapy. The latter can exert not only beneficial ...