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Advances in sickle cell disease treatment: From drug discovery until the patient monitoring
(2011-04-01)
Sickle Cell Disease (SCD) is one of the most prevalent hematological diseases in the world. Despite the immense progress in molecular knowledge about SCD in last years few therapeutical sources are currently available. ...
Advances in sickle cell disease treatment: From drug discovery until the patient monitoring
(2011-04-01)
Sickle Cell Disease (SCD) is one of the most prevalent hematological diseases in the world. Despite the immense progress in molecular knowledge about SCD in last years few therapeutical sources are currently available. ...
κ Opioid receptor-mediated depression of activity evoked in convergent dorsal horn cells by thermal and non-thermal noxious stimulation
(1990)
The response of convergent dorsal horn cells to tonic and phasic noxiuos heating and to noxious pinching was studied and after topical application of a solution (30 nmol) of the κ agonist U-50,488H to the dorsal surface ...
Opioidergic and GABAergic mechanisms in the rostral ventromedial medulla modulate the nociceptive response of vocalization in guinea pigs
(PERGAMON-ELSEVIER SCIENCE LTD, 2010)
Vocalization generated by the application of a noxious stimulus is an integrative response related to the affective-motivational component of pain. The rostral ventromedial medulla (RVM) plays an important role in descending ...
Endogenous opioid peptide-mediated neurotransmission in central and pericentral nuclei of the inferior colliculus recruits mu(1)-opioid receptor to modulate post-ictal antinociception
(CHURCHILL LIVINGSTONEEDINBURGH, 2012-02)
Background: The aim of the present work was to investigate the involvement of the mu(1)-endogenous opioid peptide receptor-mediated system in post-ictal antinociception. Methods: Antinociceptive responses were determined ...
Involvement of the opioid system in the development and expression of sensitization to the locomotor-activating effect of ethanol
(Cambridge Univ Press, 2000-12-01)
Previous studies have shown that pretreatment with naloxone (Nlx), an opiate antagonist, attenuates the stimulating effect of ethanol. the purpose of the present study was to determine the influence of Nix on the development ...
Analgesia produced by intrathecal administration of the k opioid agonist, U-50,488H, on formalin-evoked cutaneous pain in the rat
(1990)
The antinociceptive activity of the selective k opioid agonist U-50,488H, given intrathecally (i.t.) against chemically induced cutaneous pain in rats, was assessed from cumulative dose-response experiments and the formalin ...
Treating alcohol use disorder in U.S. veterans: The role of traumatic brain injury
(American Neuropsychiatric Association, 2019-10)
Objective: The authors examined the efficacy of valproate to reduce relapse to heavy drinking among veterans with alcohol use disorder (AUD) and neuropsychiatric comorbidities and whether antecedent traumatic brain injury ...
Anxiety-induced antinociception in mice: effects of systemic and intra-amygdala administration of 8-OH-DPAT and midazolam
(Springer, 2000-06-01)
Rationale: Mice exhibit antinociception after a single experience in the elevated plus maze (EPM), an animal model of anxiety. Objective: This study investigated the mechanisms involved in this form of anxiety-induced ...
Tolerance to non-opioid analgesics in PAG involves unresponsiveness of medullary pain-modulating neurons in male rats
(European Journal of Neuroscience, 2015)