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The Role of Ghrelin in Reward-Based Eating
(Elsevier Science Inc, 2012-09)
The peptide hormone ghrelin acts in the central nervous system as a potent orexigenic signal. Not only is ghrelin recognized as playing an important role in feeding circuits traditionally thought of as affecting body weight ...
Is ghrelin synthesized in the central nervous system?
(Molecular Diversity Preservation International, 2017-03)
Ghrelin is an octanoylated peptide that acts via its specific receptor, the growth hormone secretagogue receptor type 1a (GHSR-1a), and regulates a vast variety of physiological functions. It is well established that ghrelin ...
Des-acyl ghrelin and ghrelin O-acyltransferase regulate hypothalamic-pituitary-adrenal axis activation and anxiety in response to acute stress
(Endocrine Society, 2016-10)
Ghrelin exists in two forms in circulation, acyl ghrelin and des-acyl ghrelin, both of which have distinct and fundamental roles in a variety of physiological functions. Despite this fact, a large proportion of papers ...
Plasma levels of acylated and total ghrelin in pediatric patients with chronic kidney disease
(Springer, 2010-12-01)
This cross-sectional study set out to compare total and acyl ghrelin levels in children with mild chronic kidney disease (CKD) undergoing conservative treatment (n = 19) with children with end-stage renal disease (ESRD) ...
Expression of ghrelin and Its receptor mRNA in ovibne oocyte and cumulus cells
(Royan Inst, 2018-10)
Energy balance is regulated by ghrelin which is a neuroendocrine modulator. Ghrelin is expressed in reproductive organs. However, the role of ghrelin during in vitro maturation (IVM) and bovine preimplantational development ...
Role of ghrelin in fertilization, early embryo development, and implantation periods
(Bioscientifica, 2015-06)
In order to clarify the physiological role of ghrelin in gestation, we evaluated the effects of administration of exogenous ghrelin (2 or 4 nmol/animal per day) or its antagonist (6 nmol/animal per day of (D-Lys3)GHRP6) ...
Ghrelin Selectively Inhibits CaV3.3 Subtype of Low-Voltage-Gated Calcium Channels
(Humana Press, 2019-08-29)
The mechanisms by which ghrelin controls electrical activity in the hypothalamus are not fully understood. One unexploredtarget of ghrelin is CaV3, responsible for transient calcium currents (T-currents) that control ...
Novel mechanisms of growth hormone regulation: growth hormone-releasing peptides and ghrelin
(Associação Brasileira de Divulgação Científica, 2006-08-01)
Growth hormone secretion is classically modulated by two hypothalamic hormones, growth hormone-releasing hormone and somatostatin. A third pathway was proposed in the last decade, which involves the growth hormone ...
Ghrelin plasma levels in patients with idiopathic short stature
(2011)
Background: Novel molecular insights have suggested that ghrelin may be involved in the pathogenesis of some forms of short stature. Recently, growth hormone secretagogue receptor (GHSR) mutations that segregate with short ...