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Mostrando ítems 151-160 de 230
Nicotine modulates mitochondrial dynamics in hippocampal neurons
(Springer, 2022)
Nicotinic acetylcholine receptor dysfunction in addiction and in some neurodegenerative and neuropsychiatric diseases
(Multidisciplinary Digital Publishing Institute, 2023)
Distinct evolutionary trajectories of neuronal and hair cell nicotinic acetylcholine receptors
(Oxford University Press, 2019-12)
The expansion and pruning of ion channel families has played a crucial role in the evolution of nervous systems. Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels with distinct roles in synaptic ...
Interaction of Bupropion with Muscle-Type Nicotinic Acetylcholine Receptors in Different Conformational States
(American Chemical Society, 2009-06-30)
To characterize the binding sites and the mechanisms of inhibition of bupropion on muscle-type nicotinic acetylcholine receptors (AChRs), structural and functional approaches were used. The results established that bupropion: ...
Effects of VAChT reduction and α7nAChR stimulation by PNU-282987 in lung inflammation in a model of chronic allergic airway inflammation
(Elsevier, 2020-09-05)
The cholinergic anti-inflammatory pathway has been shown to regulate lung inflammation and cytokine release in acute models of inflammation, mainly via α7 nicotinic receptor (α7nAChR). We aimed to evaluate the role of ...
GaAs laser therapy reestablishes the morphology of the NMJ and nAChRs after injury due to bupivacaine
(2017-02-01)
Background Local anesthetics are used to relieve pre- and postoperative pain, acting on both sodium channels and nicotinic acetylcholine receptors (nAChR) at the neuromuscular junction (NMJ). Bupivacaine acts as a ...
SK2 channels are required for function and long-term survival of efferent synapses on mammalian outer hair cells
(Academic Press Inc Elsevier Science, 2009-01)
Cochlear hair cells use SK2 currents to shape responses to cholinergic efferent feedback from the brain. Using SK2-/- mice, we demonstrate that, in addition to their previously defined role in modulating hair cell membrane ...