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Prenatal restraint stress decreases the expression of Alpha-7 Nicotinic receptor in the brain of adult rat offspring
(Taylor & Francis Ltd, 2015-02)
Prenatal stress (PS) strongly impacts fetal brain development and function in adulthood. In normal aging and Alzheimer's disease, there is hypothalamic–pituitary–adrenal axis dysfunction and loss of cholinergic neurons and ...
The α10 nicotinic acetylcholine receptor subunit is required for normal synaptic function and integrity of the olivocochlear system
(National Academy of Sciences, 2007-12)
Although homomeric channels assembled from the α9 nicotinic acetylcholine receptor (nAChR) subunit are functional in vitro, electrophysiological, anatomical, and molecular data suggest that native cholinergic olivocochlear ...
The smoking gun in nicotine-induced anorexia
(Elsevier, 2011-08)
Hypothalamic pro-opiomelanocortin (POMC) neurons are the major source of anorectic melanocortin peptides in the brain. A recent study (Mineur et al., 2011) demonstrates that nicotine directly stimulates arcuate POMC neurons ...
The Nemertine Toxin Anabaseine and Its Derivative DMXBA (GTS-21): Chemical and Pharmacological Properties
(Molecular Diversity Preservation International, 2006-04)
Nemertines are a phylum of carnivorous marine worms that possess a variety of alkaloidal, peptidic or proteinaceous toxins that serve as chemical defenses against potential predators. The hoplonemertines additionally ...
A novel pharmacological activity of caffeine in the cholinergic system
(Pergamon-Elsevier Science Ltd, 2018-06)
Cholinergic deficit is regarded as an important factor responsible for Alzheimer's disease (AD) symptoms. Acetylcholinesterase (AChE) and nicotinic receptor (AChR) are two molecular targets for the treatment of this disease. ...
Transient Cholesterol Effects on Nicotinic Acetylcholine Receptor Cell-Surface Mobility
(Public Library of Science, 2014-06)
To what extent do cholesterol-rich lipid platforms modulate the supramolecular organization of the nicotinic acetylcholine receptor (AChR)? To address this question, the dynamics of AChR particles at high density and its ...
A gain-of-function mutation in the α9 nicotinic acetylcholine receptor alters medial olivocochlear efferent short-term synaptic plasticity
(Society for Neuroscience, 2018-04)
Gain control of the auditory system operates at multiple levels. Cholinergic medial olivocochlear (MOC) fibers originate in the brainstem and make synaptic contacts at the base of the outer hair cells (OHCs), the final ...
Estudos computacionais e síntese de potenciais agonistas de receptores nicotínicos de acetilcolina (subtipo α7) visando o tratamento da doença de Alzheimer
(Universidade Estadual Paulista (Unesp), 2021-11-25)
Os receptores nicotínicos de acetilcolina estão relacionados a doenças como esquizofrenia, dependência química (álcool e tabaco), epilepsia, doença de Alzheirmer, ansiedade e doença de Parkinson. Dentre os receptores ...
Spatiotemporal dynamics of nicotinic acetylcholine receptors and lipid platforms
(Springer, 2017)
Abstract: The relationships between neurotransmitter receptors and their membrane environment are complex, mutual (bidirectional) and physiologically important. Some of these relationships are established with subsets of ...