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(E)-3-Furan-2-yl- N- p-tolyl-acrylamide and its Derivative DM489 Decrease Neuropathic Pain in Mice Predominantly by α7 Nicotinic Acetylcholine Receptor Potentiation
(American Chemical Society, 2020-10-19)
The main objective of this study was to determine whether (E)-3-furan-2-yl-N-p-tolyl-acrylamide (PAM-2) and its structural derivative DM489 produce anti-neuropathic pain activity using the streptozotocin (STZ)- and ...
Lovastatin differentially regulates α7 and α4 neuronal nicotinic acetylcholine receptor levels in rat hippocampal neurons
(MDPI, 2020)
Abstract: Neuronal 7 and 4 2 are the predominant nicotinic acetylcholine receptor (nAChR)
subtypes found in the brain, particularly in the hippocampus. The e ects of lovastatin, an inhibitor of
cholesterol biosynthesis, ...
Differential region-specific regulation of α4β2* nAChRs by self-administered and non-contingent nicotine in C57BL/6J mice
(Wiley Blackwell Publishing, Inc, 2010-10)
Neuronal nAChR upregulation is the hallmark of chronic nicotine exposure. Neuroplasticity to abused drugs, however, depends on whether their administration is forced by the experimenter or is under the control of the ...
Charged amino acid motifs flanking each extreme of the αM4 transmembrane domain are involved in assembly and cell-surface targeting of the muscle nicotinic acetylcholine receptor
(Wiley-liss, Div John Wiley & Sons Inc, 2007-02-27)
The αM4 transmembrane domain of the nicotinic acetylcholine receptor (AChR) is flanked by two basic amino acids (His408 and Arg429) located at its cytoplasmic‐ and extracellular‐facing extremes, respectively, at the level ...
Nicotinic α4 receptor-mediated cholinergic influences on food intake and activity patterns in hypothalamic circuits
(Public Library of Science, 2015)
Abstract: Nicotinic acetylcholine receptors (nAChRs) play an important role in regulating appetite and have been shown to do so by influencing neural activity in the hypothalamus. To shed light on the hypothalamic circuits ...
Role of the cys loop and transmembrane domain in the allosteric modulation of α4β2 nicotinic acetylcholine receptors
(American Society for Biochemistry and Molecular Biology Inc., 2017)
© 2017 by The American Society for Biochemistry and Molecular Biology, Inc.Allosteric modulators of pentameric ligand-gated ion channels are thought to act on elements of the pathways that couple agonist binding to channel ...
Design, synthesis and functional evaluation of a novel series of phosphonate-functionalized 1,2,3-triazoles as positive allosteric modulators of α7 nicotinic acetylcholine receptors
(American Chemical Society, 2020-07-28)
The α7 nicotinic acetylcholine receptor is a pentameric ligand-gated ion channel widely distributed in the central nervous system, mainly in hippocampus and cortex. The enhancement of its activity by positive allosteric ...
Adaptive evolution in mammalian proteins involved in cochlear outer hair cell electromotility
(Academic Press Inc Elsevier Science, 2006-12)
Somatic electromotility in cochlear outer hair cells, as the basis for cochlear amplification, is a mammalian novelty and it is largely dependent upon rapid cell length changes proposed to be mediated by the motor-protein ...
Homomeric and heteromeric α7 nicotinic acetylcholine receptors in health and some central nervous system diseases
(Multidisciplinary Digital Publishing Institute, 2021)
Abstract: Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand-gated ion channels
involved in the modulation of essential brain functions such as memory, learning, and attention.
Homomeric α7 nAChR, formed ...