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Impaired frequencies and function of platelets and tissue remodeling in chronic Chagas disease
(Public Library of Science, 2019-06)
Chronic inflammation, as a consequence of the persistent infection with Trypanosoma cruzi, leads to continuous activation of the immune system in patients with chronic Chagas disease. We have previously shown that increased ...
Deletion of interleukin-6 prevents cardiac inflammation, fibrosis and dysfunctionwithout affecting blood pressure in angiotensin II-high salt-induced hypertension
(Lippincott Williams, 2015-01)
Objective: Inflammation has been proposed as a key component in the development of hypertension and cardiac remodeling associated with different cardiovascular diseases. However, the role of the proinflammatory cytokine ...
Angiotensin-II-Evoked Ca2+ Entry in Murine Cardiac Fibroblasts Does Not Depend on TRPC Channels
(Molecular Diversity Preservation International, 2020-01)
TRPC proteins form cation conducting channels regulated by different stimuli and are regulators of the cellular calcium homeostasis. TRPC are expressed in cardiac cells including cardiac fibroblasts (CFs) and have been ...
Cardiac-deleterious role of galectin-3 in chronic Angiotensin II-induced hypertension
(American Physiological Society, 2016-11)
Galectin- 3 (Gal-3), a member of the β-galactoside lectin family, has an important role in immune regulation. In hypertensive rats and heart failure patients, Gal-3 is considered a marker for an unfavorable prognosis. ...
The activation of the G protein-coupled estrogen receptor (GPER) prevents and regresses cardiac hypertrophy
(Elsevier Inc, 2020-02-01)
Ventricular hypertrophy is a risk factors for arrhythmias, ischemia and sudden death. It involves cellular modifications leading to a pathological remodeling and is associated with heart failure. The activation of the G ...
Carbonic anhydrase inhibitors reduce cardiac dysfunction after sustained coronary artery ligation in rats
(Elsevier Science Inc, 2016-11)
Background Two potent carbonic anhydrase (CA) inhibitors with widely differing membrane permeability, poorly diffusible benzolamide (BZ), and highly diffusible ethoxzolamide (ETZ) were assessed to determine whether they ...
Remodelación cardiaca en pacientes con infarto de miocardio secundario a herida penetrante de corazónCardiac remodeling in patients with myocardial infarction secondary to penetrating heart wound
(Asociación Colombiana de Medicina InternaRehabilitación en SaludBogotá, Colombia, 2021)
Treatment with Fenofibrate plus a low dose of Benznidazole attenuates cardiac dysfunction in experimental Chagas disease
(Elsevier, 2017-12)
Trypanosoma cruzi induces serious cardiac alterations during the chronic infection. Intense inflammatory response observed from the beginning of infection, is critical for the control of parasite proliferation and evolution ...