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Relevance of cystein-rich secretory proteins for male fertility
(Fundación Revista Medicina, 2019)
Cysteine-Rich Secretory Protein (CRISP) 1, 2, 3 and 4 are mainly expressed in thereproductive tract and have key roles in mammalian fertilization. In spite of this,knockout (KO) mice for each individual protein are fertile ...
Inflammation and Spermatogenesis
(CRC Press - Taylor & Francis Group, 2018)
The testis is an immunologically privileged site with a unique immunosuppressor microenvironment able to tolerate haploid germ cell antigens that appear at puberty and to easily accept tissue grafts. However, this ...
Behavioural switching during oscillations of intracellular Ca2+ concentration in free-swimming human sperm
(BioScientifica, 2021-03-09)
A human sperm must swim to the egg to fertilise it. To do this the sperm uses different types of swimming (behaviours) as they are needed. When we watch sperm swimming we see that they regularly change behaviour, sometimes ...
Relevance of angiogenesis in autoimmune testis inflammation
(Oxford University Press, 2020-12)
Experimental autoimmune orchitis (EAO) is a useful model to study organ-specific autoimmunity and chronic testicular inflammation. This model reflects testicular pathological changes reported in immunological infertility ...
Autoimmune orchitis and autoimmune oophoritis
(Academic Press Inc Elsevier Science, 2019)
Experimental studies predict a frequent occurrence of human gonadal autoimmunity. In spontaneous multi-organ models of autoimmune diseases, the testis and ovary are frequent targets. Although progress in clinical research ...
Functional redundancy and compensation: deletion of multiple murine Crisp genes reveals their essential role for male fertility
(Federation of American Societies for Experimental Biology, 2020-12)
Mammalian Cysteine-RIch Secretory Protein (CRISP) family includes four members present in sperm and reported to regulate Ca2+ channels and fertilization. Based on our previous observations using single knockouts models and ...
A novel combination of γ-tocopherol-rich mixture of tocopherols and ascorbic acid restores fertility in cases of tyrosine nitration-associated male infertility in mice
(Molecular Diversity Preservation International, 2020-07-13)
Infertility is an important health problem that affects up to 16% of couples worldwide. Male infertility is responsible for 50% of the cases. Currently, a physical examination, hormone profiling and the evaluation of two ...
Functional redundancy and compensation: Deletion of multiple murine Crisp genes reveals their essential role for male fertility
(Federation of American Societies for Experimental Biology, 2020-10)
Mammalian Cysteine-RIch Secretory Protein (CRISP) family includes four members present in sperm and reported to regulate Ca2+ channels and fertilization. Based on our previous observations using single knockouts models and ...
Obesity alters the ovarian glucidic homeostasis disrupting the reproductive outcome of female rats
(Elsevier Science Inc, 2017-04)
Obesity constitutes a health problem of increasing worldwide prevalence related to many reproductive problems such as infertility, ovulation dysfunction, preterm delivery, fetal growth disorders, etc. The mechanisms linking ...