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Properties of mutated murine α4β2 nicotinic receptors linked to partial epilepsy
(Elsevier Ireland, 2008-03)
We characterized, by electrophysiological methods, two biophysical properties of murine recombinant α4β2 nicotinic acetylcholine receptors (nAChR) bearing a mutation (α4:+L264α4:β2 or α4:S252Fα4:β2) linked to autosomal ...
The nicotinic acetylcholine receptor as a molecular machine for neuromuscular transmission
(Elsevier, 2018-08)
The nicotinic acetylcholine receptor (nAChR) has crucial functions at the neuromuscular junction (NMJ). It belongs to the superfamily of pentameric ligand-gated ion channels and has become the stereotype for probing ...
Anesthetics as chemical tools to study the structure and function of nicotinic acetylcholine receptors
(Bentham Science Publishers, 2005-10)
The nicotinic acetylcholine receptor (AChR) is the archetype of the Cys-loop ligand-gated ion channel'receptor superfamily. Noncompetitive antagonists inhibit the AChR without interacting directly with agonist sites. Among ...
Nicotinic receptor M3 transmembrane domain: Position 8′ contributes to channel gating
(American Society for Pharmacology and Experimental Therapeutics, 2002-08-01)
The nicotinic acetylcholine receptor (nAChR) is a pentamer of homologous subunits with composition α2βεδ in adult muscle. Each subunit contains four transmembrane domains (M1-M4). Position 8′ of the M3 domain is phenylalanine ...
Unravelling the molecular players at the cholinergic efferent synapse of the zebrafish lateral line
(Society for Neuroscience, 2020-11)
The lateral line (LL) is a sensory system that allows fish and amphibians to detect water currents. LL responsiveness is modulated by efferent neurons which aid to distinguish between external and self-generated stimuli, ...
Functional and structural interaction of (-)-Reboxetine with the human α4β2 nicotinic acetylcholine receptor
(American Society for Pharmacology and Experimental Therapeutics, 2013-01)
The interaction of the selective norepinephrine reuptake inhibitor (-)-reboxetine with the human α4β2 nicotinic acetylcholine receptor (nAChR) in different conformational states was studied by several functional and ...
Autoimmune Attack of the Neuromuscular Junction in Myasthenia Gravis: Nicotinic Acetylcholine Receptors and Other Targets
(American Chemical Society, 2019-04)
The nicotinic acetylcholine receptor (nAChR) family, the archetype member of the pentameric ligand-gated ion channels, is ubiquitously distributed in the central and peripheral nervous systems and its members are the targets ...
Distinct evolutionary trajectories of neuronal and hair cell nicotinic acetylcholine receptors
(Oxford University Press, 2019-12)
The expansion and pruning of ion channel families has played a crucial role in the evolution of nervous systems. Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels with distinct roles in synaptic ...
Interaction of Barbiturate Analogs with the Torpedo californica Nicotinic Acetylcholine Receptor Ion Channel
(American Society for Pharmacology and Experimental Therapeutics, 2001-09)
Barbiturate-induced anesthesia is a complex mechanism that probably involves several ligand-gated ion channel superfamilies. One of these superfamilies includes the archetypical nicotinic acetylcholine receptor (nAChR), ...
Functional nicotinic acetylcholine receptor reconstitution in Au(111)-supported Thiolipid Monolayers
(Royal Society of Chemistry, 2015-10)
The insertion and function of the muscle-type nicotinic acetylcholine receptor (nAChR) in Au(111)- supported thiolipid self-assembled monolayers have been studied by atomic force microscopy (AFM), surface plasmon resonance ...