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Second generation BTK inhibitors impair the anti-fungal response of macrophages and neutrophils
(Wiley-liss, div John Wiley & Sons Inc., 2020-04)
BTK inhibitors (BTKi) play a major role in the treatment of Chronic Lymphocytic Leukemia (CLL). Ibrutinib, the first in class BTKi, impairs macrophage and neutrophil functions and also cell-mediated effector mechanisms of ...
Pro-inflammatory monocyte profile in patients with major depressive disorder and suicide behaviour and how ketamine induces antiinflammatory M2 macrophages by NMDAR and mTOR
(The Lancet, 2019-12)
Background: Depression is a highly prevalent disorder that is one of the leading causes of disability worldwide. Despite an unknown aetiology, evidence suggests that the innate and adaptive immune systems play a significant ...
Nebulizing novel multifunctional nanovesicles: The impact of macrophage-targeted-pH-sensitive archaeosomes on a pulmonary surfactant
(Royal Society of Chemistry, 2017-09)
In this study, a NE-U22 vibrating mesh Omron nebulizer was used to deliver the Lissamine™ rhodamine B 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine triethylammonium salt (Rh-PE) and 8-hydroxypyrene-1,3,6-trisulfonic ...
PD-L2 negatively regulates Th1-mediated immunopathology during Fasciola hepatica infection
(Karger, 2016-10)
Macrophage plasticity is critical for controlling inflammation including thoseproduced by helminth infections, where alternatively activated macrophages (AAM)are accumulated in tissues. AAM expressing the co-inhibitory ...
Synthesis, antileishmanial activity and cytotoxicity of 2,3-diaryl- and 2,3,8-trisubstituted imidazo[1,2-a]pyrazines
(Elsevier, 2015)
A series of original 2-phenyl-3-(pyridin-4-yl)imidazo[1,2-a]pyrazines and the 3-iodo precursors, bearing a polar moiety at the C-8 position, was synthesized and evaluated for their antileishmanial activities. Two derivatives ...
Ultra-small solid archaeolipid nanoparticles for active targeting to macrophages of the inflamed mucosa
(Future Medicine, 2017-04)
Aim: Develop nanoparticulate agents for oral targeted delivery of dexamethasone (Dex) to macrophages of inflamed mucosa. Materials & methods: Solid archaeolipid nanoparticles (SAN-Dex) (compritol/Halorubrum tebenquichense ...
Enhanced photodynamic leishmanicidal activity of hydrophobic zinc phthalocyanine within archaeolipids containing liposomes
(Dove Press, 2014-07)
In this work, the in vitro anti-Leishmania activity of photodynamic liposomes made of soybean phosphatidylcholine, sodium cholate, total polar archaeolipids (TPAs) extracted from the hyperhalophile archaea Halorubrum ...
ENDOGENOUS INTERLEUKIN-12 REGULATES MACROPHAGE PHAGOCYTOSIS OF SPOROTHRIX SCHENCKII
(Revista de la Facltad de Ciencias Médicas, 2017)