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Mostrando ítems 11-20 de 22
Modificaciones en el proteome celular y su aplicación en la clínica
(Medicina (Buenos Aires), 2019-10)
Las modificaciones postraduccionales (PTMs por su nombre en inglés) son modificaciones covalentes en las proteínas durante o posteriores a su síntesis. Las más conocidas son fosforilación, metilación y acetilación, también ...
von Hippel-Lindau mutants in renal cell carcinoma are regulated by increased expression of RSUME
(Nature Publishing Group, 2019-04)
Renal cell carcinoma (RCC) is the major cause of death among patients with von Hippel-Lindau (VHL) disease. Resistance to therapies targeting tumor angiogenesis opens the question about the underlying mechanisms. Previously ...
Epigenetic mechanisms and posttranslational Modifications in systemic lupus erythematosus
(International Journal of Molecular Sciences, 2020)
Role of RSUME in inflammation and cáncer
(Elsevier Science, 2015)
Neddylation regulates excitatory synaptic transmission and plasticity
(Nature Publishing Group, 2019-11)
Post-translational modifications, like phosphorylation, ubiquitylation, and sumoylation, have been shown to impact on synaptic neurotransmission by modifying pre- and postsynaptic proteins and therefore alter protein ...
Stress, alcohol and infection during early development: a brief review of common outcomes and mechanisms.
(Wiley Blackwell Publishing, Inc, 2018-10)
Although stress is an adaptive physiological response to deal with adverse conditions, its occurrence during the early stages of life, such as infancy or adolescence, can induce adaptations in multiple physiological systems, ...
Protein stabilization by RSUME accounts for PTTG pituitary tumor abundance and oncogenicity
(BioScientifica, 2018-06)
Increased levels of the proto-oncogene pituitary tumor-transforming gene 1 (PTTG) have been repeatedly reported in several human solid tumors, especially in endocrine-related tumors such as pituitary adenomas. Securin PTTG ...
SUMO conjugation as regulator of the glucocorticoid receptor-FKBP51 cellular response to stress
(Elsevier Science Inc, 2019-11)
In order to adequately respond to stressful stimuli, glucocorticoids (GCs) target almost every tissue of the body. By exerting a negative feedback loop in the hypothalamic–pituitary–adrenal (HPA) axis GCs inhibit their own ...
Uncharacterized conserved motifs outside the HD-Zip domain in HD-Zip subfamily I transcription factors; a potential source of functional diversity
(BioMed Central, 2011-03)
Background: Plant HD-Zip transcription factors are modular proteins in which a homeodomain is associated to a leucine zipper. Of the four subfamilies in which they are divided, the tested members from subfamily I bind in ...
RSUME inhibits VHL and regulates its tumor supressor function
(Nature Publishing Group, 2015-09-10)
Somatic mutations or loss of von Hippel-Lindau (pVHL) happen in the majority of VHL disease tumors, which present a constitutively active Hypoxia Inducible Factor (HIF), essential for tumor growth. Recently described ...