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SPARC (secreted protein acidic and rich in cysteine) knockdown protects mice from acute liver injury by reducing vascular endothelial cell damage
(Nature Publishing Group, 2015-01)
Secreted protein, acidic and rich in cysteine (SPARC) is involved in many biological process including liver fibrogenesis, but its role in acute liver damage is unknown. To examine the role of SPARC in acute liver injury, ...
Chronic hepatitis B: The interplay between intrahepatic lymphocyte population and viral antigens in relation to liver damage
(Wiley Blackwell Publishing, Inc, 2019-02-09)
In Chronic hepatitis B (CHB) infection, virus and immune response interplay is thought to be responsible for pathogenesis. Yet, the impact of each immune cell population and viral protein expression in liver damage is still ...
Liver traumaTraumatismo hepático
(Instituto de Cirugía de la Facultad de Medicina de la Universidad Austral de Chile y el Servicio de Cirugía del Hospital Clínico Regional de Valdivia, 2018)
Naringin attenuates liver damage in streptozotocin-induced diabetic rats
(Elsevier France-editions Scientifiques Medicales Elsevier, 2018-09)
The aim of this study was to evaluate whether NAR has a hepatoprotective role in a model of STZ-induced diabetes and to elucidate the underlying mechanisms triggered by the flavonoid. Male Wistar rats were divided into ...
Metalloproteinases in non-alcoholic fatty liver disease and their behavior in liver fibrosis
(De Gruyter, 2018-12)
Non-alcoholic fatty liver disease (NAFLD) is a clinical entity of high prevalence in the world characterized by fatty infiltration of liver tissue in the absence of alcohol consumption. The natural history of the disease ...
N -Acetyl- l -Cysteine treatment efficiently prevented pre-diabetes and inflamed-dysmetabolic liver development in hypothalamic obese rats
(Pergamon-Elsevier Science Ltd, 2018-04)
AimHypothalamic obese rats are characterized by pre-diabetes, dyslipidemia, hyperadiposity, inflammation and, liver dysmetabolism with oxidative stress (OS), among others. We studied endocrine-metabolic dysfunctions and, ...
The offspring from rats fed a fatty diet display impairments in the activation of liver peroxisome proliferator activated receptor alpha and features of fatty liver disease
(Elsevier Ireland, 2020-07)
Maternal obesity programs liver derangements similar to those of NAFLD. Our main goal was to evaluate whether these liver anomalies were related to aberrant PPARα function. Obesity was induced in female Albino-Wistar rats ...
Proteome variation of the rat liver after static cold storage assayed in an ex vivo model
(Academic Press Inc Elsevier Science, 2018-12)
Cold storage is a common procedure for liver preservation in a transplant setting. However, during cold ischemia, the liver suffers molecular alterations that can affect its performance. Also, deleterious mechanisms set ...
Metastasis-associated lung adenocarcinoma transcript 1 as a common molecular driver in the pathogenesis of nonalcoholic steatohepatitis and chronic immune-mediated liver damage
(Wiley, 2018-06)
Long noncoding RNAs (lncRNAs) are functional molecules that orchestrate gene expression. To identify lncRNAs involved in nonalcoholic fatty liver disease (NAFLD) severity, we performed a multiscale study that included: (a) ...