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RSUME enhances Glucocorticoid Receptor SUMOylation and transcriptional activity
(American Society for Microbiology, 2013-06)
Glucocorticoid receptor (GR) activity is modulated by posttranslational modifications, including phosphorylation, ubiquitination, and SUMOylation. The GR has three SUMOylation sites: lysine 297 (K297) and K313 in the ...
SUMOylation and deimination of proteins: two epigenetic modifications involved in Giardia encystation
(Elsevier, 2014-04)
SUMOylation, a post-translational modification of proteins, has been recently described as vital in eukaryotic cells. In a previous work, we analyzed the role of SUMO protein and the genes encoding the putative enzymes of ...
Modifications in the cellular proteome and their clinical application
(Medicina (Buenos Aires), 2019-12)
Post-translational modifications (PTMs) are covalent modifications in proteins during or after their synthesis. Among them, the best known are phosphorylation, methylation, acetylation, and also cleavage or binding of small ...
SUMOylation Pathway in Trypanosoma cruzi: Functional Characterization and Proteomic Analysis of Target Proteins
(American Society for Biochemistry and Molecular Biology, 2011-11)
SUMOylation is a relevant protein post-translational modification in eukaryotes. The C terminus of proteolytically activated small ubiquitin-like modifier (SUMO) is covalently linked to a lysine residue of the target protein ...
Early responses of maize seedlings to Cu stress include sharp decreases in gibberellins and jasmonates in the root apex
(Springer Wien, 2020-04)
Copper (Cu) interferes with numerous biological functions in plants, including plant growth, which is partly governed by plant hormones. In the present study, Cu stress effect on the roots of pre-emerging maize seedlings ...
The activity of the glucocorticoid receptor is regulated by SUMO conjugation to FKBP51
(Nature Publishing Group, 2016-10)
FK506-binding protein 51 (FKBP51) regulates the activity of the glucocorticoid receptor (GR), and is therefore a key mediator of the biological actions of glucocorticoids. However, the understanding of the molecular ...
SUMO conjugation to spliceosomal proteins is required for efficient pre-mRNA splicing
(Oxford University Press, 2017-06)
Pre-mRNA splicing is catalyzed by the spliceosome, a multi-megadalton ribonucleoprotein machine. Previous work from our laboratory revealed the splicing factor SRSF1 as a regulator of the SUMO pathway, leading us to explore ...
Modification of Akt by SUMO conjugation regulates alternative splicing and cell cycle
(Landes Bioscience, 2013-08)
Akt/PKB is a key signaling molecule in higher eukaryotes and a crucial protein kinase in human health and disease. Phosphorylation, acetylation, and ubiquitylation have been reported as important regulatory post-translational ...
When SUMO met splicing
(Landes Bioscience, 2018-06)
Spliceosomal proteins have been revealed as SUMO conjugation targets. Moreover, we have reported that many of these are in a SUMO-conjugated form when bound to a pre-mRNA substrate during a splicing reaction. We demonstrated ...
SUMO polymeric chains are involved in nuclear foci formation and chromatin organization in Trypanosoma brucei procyclic forms
(Public Library of Science, 2018-02)
SUMOylation is a post-translational modification conserved in eukaryotic organisms that involves the covalent attachment of the small ubiquitin-like protein SUMO to internal lysine residues in target proteins. This tag ...