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MicroRNA dysregulation in pulmonary arteries from chronic obstructive pulmonary disease: Relationships with vascular remodeling
(American Thoracic Society, 2018-10)
Pulmonary vascular remodeling is an angiogenic-related process involving changes in smooth muscle cell (SMC) homeostasis, which is frequently observed in chronic obstructive pulmonary disease (COPD). MicroRNAs (miRNAs) are ...
Isoprenylcysteine carboxy methyltransferase (ICMT) is associated with tumor aggressiveness and its expression is controlled by the p53 tumor suppressor
(American Society for Biochemistry and Molecular Biology, 2019-03)
Isoprenyl cysteine carboxyl methyltransferase (ICMT) plays a key role in post-translational regulation of prenylated proteins. On the basis of previous results, we hypothesized that the p53 pathway and ICMT expression may ...
Novel genetic loci affecting facial shape variation in humans
(eLife Sciences Publications Ltd, 2019-11)
The human face represents a combined set of highly heritable phenotypes, but knowledge on its genetic architecture remains limited, despite the relevance for various fields. A series of genome wide association studies on ...
A novel heterozygous STAT5B variant in a patient with short stature and partial growth hormone insensitivity (GHI)
(Churchill Livingstone, 2020-02)
Background: The most frequent monogenic causes of growth hormone insensitivity (GHI) include defects in genes encoding the GH receptor itself (GHR), the signal transducer and activator of transcription (STAT5B), the insulin ...
Differential regulation of ovarian anti-müllerian hormone (AMH) by estradiol through α- and β-estrogen receptors
(Endocrine Society, 2012-09)
Background: Anti-Müllerian hormone (AMH) is a member of the TGF-β family, which limits follicle maturation. Recently serum AMH has been recognized as a useful diagnostic and prognostic tool in human reproductive endocrinology. ...
Natural anthraquinones as novel photosentizers for antiparasitic photodynamic inactivation
(Elsevier Gmbh, 2019-08)
Cutaneous leishmaniasis (CL) is a vector-borne disease caused by obligate protist parasites from the genus Leishmania. The potential toxicity as well as the increased resistance of standard treatments has encouraged the ...
Heme oxygenase 1 (HO-1) challenges the angiogenic switch in prostate cancer
(Springer, 2011-12)
Prostate cancer (PCa) is the second leading cause of cancer-associated death in men. Once a tumor is established it may attain further characteristics via mutations or hypoxia, which stimulate new blood vessels. Angiogenesis ...
Effect of progesterone and first evidence about allopregnanolone action on the progression of epithelial human ovarian cancer cell lines
(Pergamon-Elsevier Science Ltd, 2019-10)
Ovarian cancer (OvCa) has the highest morbidity among all gynecologic cancers worldwide, and its distant metastasis is one of main causes for the poor prognosis of OvCa patients. Our previous studies have reported that ...
SOX9 and SF1 are involved in cyclic AMP-mediated upregulationof anti-Müllerian gene expression in the testicular prepubertal Sertoli cell line SMAT1
(American Physiological Society, 2011-09)
In Sertoli cells, anti-Müllerian hormone (AMH) expression is upregulated by FSH via cyclic AMP (cAMP), although no classical cAMP response elements exist in the AMH promoter. The response to cAMP involves NF-κB and AP2; ...
Myosin VI Reduces Proliferation, but Not Differentiation, in Pluripotent P19 Cells
(Public Library of Science, 2013-05-17)
Background:We have previously shown marked upregulation of the mRNA and corresponding protein for the cellular motor molecule myosin VI (Myo6) after an extremely traumatic stress experience, along with a delayed decrease ...