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Signaling network involved in the GPC3-induced inhibition of breast cancer progression: role of canonical Wnt pathway
(Springer, 2018-09)
Purpose: We have shown that GPC3 overexpression in breast cancer cells inhibits in vivo tumor progression, by acting as a metastatic suppressor. GPC3-overexpressing cells are less clonogenic, viable and motile, while their ...
Natural and semisynthetic diterpenoids with antiviral and immunomodulatory activities block the ERK signaling pathway
(Springer, 2015-10)
The pathogenesis of many viral infections lies on the damage caused by the immune response against the virus. Current antiviral drugs do not act on the inflammatory component of the disease. Thus, new compounds that inhibit ...
Kinase inhibitors can produce off-target effects and activate linked pathways by retroactivity
(BioMed Central, 2011-10)
Background: It has been shown in experimental and theoretical work that covalently modified signaling cascades naturally exhibit bidirectional signal propagation via a phenomenon known as retroactivity. An important ...
Alterations in the insulin signaling pathway in bovine ovaries with experimentally induced follicular persistence
(Elsevier Science Inc., 2020-12)
Reproductive diseases in dairy cows as cystic ovarian disease (COD) represent a major problem that impacts on dairy production. COD is characterized by anovulation, persistence of the dominant follicle, and interruption ...
cAMP-PKA signal transduction specificity in Saccharomyces cerevisiae
(Springer, 2020-09)
Living cells have developed a set of complex signaling responses, which allow them to withstand different environmental challenges. Signaling pathways enable the cell to monitor external and internal states and to articulate ...
Heme oxygenase activity and oxidative stress signalling in soybean leaves
(Elsevier Ireland, 2006-02)
We have previously demonstrated that the induction of heme oxygenase-1 (EC 1.14.99.3) plays a protective role for soybean plants against oxidative stress. Here, we have investigated for the first time the possible signal ...
Crosstalk between ROS-dependent apoptotic and autophagic signaling pathways in Zn(II) phthalocyanine photodynamic therapy of melanoma
(Elsevier Science Inc, 2020-01-01)
Melanoma is the most aggressive type of skin cancer, highly resistant to conventional therapies. Photodynamic therapy (PDT) is a minimally invasive treatment modality that combines the use of a photosensitizer, visible ...
Hydrogen sulphide as a guard cell network regulator
(Wiley Blackwell Publishing, Inc, 2020-11-29)
Hydrogen sulphide (H2S) is an endogenously produced gasotransmitter that has rapidly emerged as an active signalling component of several plant processes, stomatal movement regulation among them. The guard cells (GCs), ...
Trypanosoma cruzi Exploits Wnt Signaling Pathway to Promote Their Intracellular Replication in Macrophages
(Frontiers Media S.A., 2018-04)
During the acute phase of Trypanosoma cruzi infection, macrophages can act as host cells for the parasites as well as effector cells in the early anti-parasitic immune response. Thus, the targeting of specific signaling ...
Role of the ERK1/2 signaling pathway in the replication of junín and tacaribe viruses
(MDPI, 2018-04)
We have previously shown that the infection of cell cultures with the arenaviruses Junín (JUNV), Tacaribe (TCRV), and Pichindé promotes the phosphorylation of mitogen-activated protein kinases (MAPKs) extracellular ...