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Mostrando ítems 21-30 de 47
6,19-Sulfur-bridged progesterone analogues with antiimmunosuppressive activity
(American Chemical Society, 2005-09)
Sulfur-bridged pregnanes 6,19-epithioprogesterone, 21-hydroxy-6,19- epithioprogesterone, and the corresponding sulfoxides and sulfones were synthesized and tested as blockers of the immunosuppresive activity of dexamethasone ...
Down-regulation of intestinal epithelial innate response by probiotic yeasts isolated from kefir
(Elsevier Science, 2010-06)
Kefir is obtained by milk fermentation with a complex microbial population included in a matrix of polysaccharide and proteins. Several health-promoting activities has been attributed to kefir consumption. The aim of this ...
Insulin enhances leptin expression in human trophoblastic cells
(Oxford University Press, 2013-06)
Leptin, one of the adipokines that controls energy metabolism via the central nervous system, also has pleiotropic peripheral effects, acting as a proinflammatory cytokine. Leptin is also produced by trophoblastic cells ...
Successful transduction with AAV vectors after selective depletion of anti-AAV antibodies by immunoadsorption
(Cell Press, 2020-03-13)
Gene therapy with adeno-associated virus (AAV)-based vectors shows great promise for the gene therapeutic treatment of a broad array of diseases. In fact, the treatment of genetic diseases with AAV vectors is currently the ...
Phosphorylation regulates functions of ZEB1 transcription factor
(Wiley-liss, Div John Wiley & Sons Inc, 2016-03)
ZEB1 transcription factor is important in both development and disease, including many TGFβ-induced responses, and the epithelial-to-mesenchymal transition (EMT) by which many tumors undergo metastasis. ZEB1 is differentially ...
Smaug variants in neural and non-neuronal cells
(Taylor & Francis, 2016-02)
Mammalian Smaug1/Samd4a is an mRNA regulator involved in synapse plasticity and additional non-neuronal functions. Here we analyzed the expression of Smaug1/Samd4a variants and Smaug2/Samd4b in primary hippocampal neurons ...
A mutation inactivating the distal SF1 binding site on the human anti-Müllerian hormone promoter causes persistent Müllerian duct syndrome
(Oxford University Press, 2019-06)
The persistent Müllerian duct syndrome (PMDS) is a 46,XY disorder of sexual development characterized by the persistence of Müllerian duct derivatives, uterus and tubes, in otherwise normally masculinized males. The ...
Virucidal, antiviral and immunomodulatory activities of β-escin and Aesculus hippocastanum extract
(Wiley, 2018-11)
Objectives: β-Escin, one of the constituents of Aesculus hippocastanum L. (Hippocastanaceae) seed extract (AH), inhibits NF-κB activation, which plays an important role in HSV-1 replication. The aim was to examine the ...
Toll-Like Receptor 6 Plays an Important Role in Host Innate Resistance to Brucella abortus Infection in Mice
(American Society For Microbiology, 2013-05)
Brucella abortus is recognized by several Toll-like receptor (TLR)-associated pathways triggering proinflammatory responses that affect both the nature and intensity of the immune response. Previously, we demonstrated that ...
Firefly genomes illuminate parallel origins of bioluminescence in beetles
(eLife Sciences Publications, 2018-10-16)
Fireflies and their luminous courtships have inspired centuries of scientific study. Today firefly luciferase is widely used in biotechnology, but the evolutionary origin of bioluminescence
within beetles remains unclear. ...