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Topography of nicotinic acetylcholine receptor membrane-embedded domains
(American Society for Biochemistry and Molecular Biology, 2000-12)
The topography of nicotinic acetylcholine receptor (AChR) membrane-embedded domains and the relative affinity of lipids for these protein regions were studied using fluorescence methods. Intact Torpedo californica AChR ...
Bupropion inhibits human α3β4 nicotinic acetylcholine receptors by interacting with luminal and non-luminal sites
(Smart Science & Technology LLC, 2017-12)
In this work, the interaction of (±)-bupropion [(±)-BP] and (±)-2-(N-tert-butylamino)-3’-iodo-4’- azidopropiophenone [(±)-SADU-3-72] with the human (h) α3β4 nicotinic acetylcholine receptor (AChR) is determined by functional ...
(E)-3-Furan-2-yl- N- p-tolyl-acrylamide and its Derivative DM489 Decrease Neuropathic Pain in Mice Predominantly by α7 Nicotinic Acetylcholine Receptor Potentiation
(American Chemical Society, 2020-10-19)
The main objective of this study was to determine whether (E)-3-furan-2-yl-N-p-tolyl-acrylamide (PAM-2) and its structural derivative DM489 produce anti-neuropathic pain activity using the streptozotocin (STZ)- and ...
Prefrontal cortex-driven dopamine signals in the striatum show unique spatial and pharmacological properties
(Society for Neuroscience, 2020-09-28)
Dopamine (DA) signals in the striatum are critical for a variety of vital processes, including motivation, motor learning, and reinforcement learning. Striatal DA signals can be evoked by direct activation of inputs from ...
A novel α-conotoxin, PeIA, cloned from Conus pergrandis, discriminates between Rat α9α10 and α7 nicotinic cholinergic receptors
(American Society for Biochemistry and Molecular Biology, 2005-08)
The α9 and α10 nicotinic cholinergic subunits assemble to form the receptor believed to mediate synaptic transmission between efferent olivocochlear fibers and hair cells of the cochlea, one of the few examples of postsynaptic ...
Differential cholinoceptor modulation of nitric oxide isoforms in experimentally-induced inflammation of dental pulp tissue
(Wiley Blackwell Publishing, Inc, 2009-06)
Aim The aim of the study was to investigate the role of muscarinic acetylcholine receptor (mAChR) activity in the regulation of endothelial (e), neuronal (n) and inducible (i) nitric oxide synthase (NOS) activity and ...
The noncompetitive inhibitor quinacrine modifies the desensitization kinetics of muscle acetylcholine receptors
(American Society for Pharmacology and Experimental Therapeutics, 2001-08)
Quinacrine has been shown to act as a noncompetitive inhibitor of the nicotinic acetylcholine receptor (nAChR). However, its mechanism of action is still a matter of controversy. We analyzed in detail the action of quinacrine ...
Alpha 7 nicotinic acetylcholine receptor modulates lymphocyte activation
(Pergamon-Elsevier Science Ltd, 2009-09-09)
Aims: Even though the presence of α7 nicotinic receptor (nAChR) in lymphocytes has been demonstrated, its functional role still remains elusive. The aim of our study was to characterize α7 nAChRs in human lymphocytes upon ...
Distinctive modulation of dopamine release in the nucleus accumbens shell mediated by dopamine and acetylcholine receptors
(Society for Neuroscience, 2017-11-15)
Nucleus accumbens (NAc) shell shows unique dopamine (DA) signals in vivo and plays a unique role in DA-dependent behaviors such as reward-motivated learning and the response to drugs of abuse.Adisynaptic mechanism forDArelease ...
Nicotine Modulates Mitochondrial Dynamics in Hippocampal Neurons
(Humana Press, 2018-12)
Mitochondria are widely recognized as fundamental organelles for cellular physiology and constitute the main energy source for different cellular processes. The location, morphology, and interactions of mitochondria with ...