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Epidermal growth factor receptor controls glycogen phosphorylase in T cells through small GTPases of the RAS family
(American Society for Biochemistry and Molecular Biology, 2019-03-22)
We recently uncovered a regulatory pathway of the muscle isoform of glycogen phosphorylase (PYGM) that plays an important role in regulating immune function in T cells. Here, using various enzymatic, pulldown, and ...
iTAK: A Program for Genome-wide Prediction and Classification of Plant Transcription Factors, Transcriptional Regulators, and Protein Kinases
(Elsevier, 2016-12)
Transcription factors (TFs) are proteins that regulate the expression of target genes by binding to specific cis-elements in promoter regions. Transcriptional regulators (TRs) also regulate the expression of target genes; ...
Twenty‐One Novel EGFR Kinase Domain variants in Patients with Nonsmall Cell Lung Cancer
(Wiley Blackwell Publishing, Inc, 2015-11)
Somatic sequence variants in the epidermal growth factor receptor (EGFR) kinase domain are associated with sensitivity to tyrosine kinase inhibitors (TKIs) in patients with nonsmall cell lung cancer (NSCLC). Patients ...
Angiotensin II Regulation of Renal Dopamine Uptake and Na+,K+-ATPase Activity
(Karger, 2009-03)
Background/Aims: Angiotensin II (ANG II) decreases dopamine (DA) uptake in renal cortex activating AT1 receptors. We investigated the signaling pathways that mediate this action and the incidence of DA-ANG II interaction ...
An Autophagy-Related Kinase Is Essential for the Symbiotic Relationship between Phaseolus vulgaris and Both Rhizobia and Arbuscular Mycorrhizal Fungi
(American Society of Plant Biologists, 2016-09)
Eukaryotes contain three types of lipid kinases that belong to the phosphatidylinositol 3-kinase (PI3K) family. In plants and Saccharomyces cerevisiae, only PI3K class III family members have been identified. These enzymes ...
A cysteine-rich extracellular protein, LAT52, interacts with the extracellular domain of the pollen receptor kinase LePRK2
(American Society of Plant Biologist, 2002-09)
Pollen germination and pollen tube growth are thought to require extracellular cues, but how these cues are perceived and transduced remains largely unknown. Pollen receptor kinases are plausible candidates for this role; ...
The crystal structure of PknI from Mycobacterium tuberculosis shows an inactive, pseudokinase-like conformation
(Wiley Blackwell Publishing, Inc, 2017-02)
Eukaryotic-like Ser/Thr protein kinases (ePKs) have been identified in many bacterial species, where they are known to mediate signalling mechanisms that share several features with their eukaryotic counterparts. In ...
Dimer asymmetry and light activation mechanism in brucella blue-light sensor histidine kinase
(American Society for Microbiology, 2021-03)
The ability to sense and respond to environmental cues is essential for adaptation and survival in living organisms. In bacteria, this process is accomplished by multidomain sensor histidine kinases that undergo ...
Differential activation of nitric oxide synthase through muscarinic acetylcholine receptors in rat salivary glands
(Elsevier, 2000-03)
Muscarinic receptors play an important role in secretory and vasodilator responses in rat salivary glands. Nitric oxide synthase (NOS) appears to be one of the multiple effectors coupled to muscarinic receptors in both ...