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α10: A determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechanosensory hair cells
(National Academy of Sciences, 2001-03)
We report the cloning and characterization of rat α10, a previously unidentified member of the nicotinic acetylcholine receptor (nAChR) subunit gene family. The protein encoded by the α10 nAChR subunit gene is most similar ...
The Cholinergic System Contributes to the Immunopathological Progression of Experimental Pulmonary Tuberculosis
(Frontiers Research Foundation, 2021-02)
The cholinergic system is present in both bacteria and mammals and regulates inflammation during bacterial respiratory infections through neuronal and non-neuronal production of acetylcholine (ACh) and its receptors. ...
A Cys-loop mutation in the Caenorhabditis elegans nicotinic receptor subunit UNC-63 impairs but does not abolish channel function
(American Society for Biochemistry and Molecular Biology, 2011-01-28)
The nematode Caenorhabditis elegans is an established model organism for studying neurobiology. UNC-63 is a C. elegans nicotinic acetylcholine receptor (nAChR) α-subunit. It is an essential component of the levamisole-sensitive ...
Jaburetox, a urease‐derived peptide: Effects on enzymatic pathways of the cockroach Nauphoeta cinerea
(Wiley-liss, div John Wiley & Sons Inc., 2020-08)
Jaburetox is a recombinant peptide derived from one of the Canavalia ensiformis urease isoforms. This peptide induces several toxic effects on insects of different orders, including interference on muscle contractility in ...
Lovastatin differentially regulates α7 and α4 neuronal nicotinic acetylcholine receptor levels in rat hippocampal neurons
(Molecular Diversity Preservation International, 2020-10)
Neuronal α7 and α4β2 are the predominant nicotinic acetylcholine receptor (nAChR) subtypes found in the brain, particularly in the hippocampus. The effects of lovastatin, an inhibitor of cholesterol biosynthesis, on these ...
Targeting Brain α7 Nicotinic Acetylcholine Receptors in Alzheimer's Disease: Rationale and Current Status.
(Springer, 2014-11)
Alzheimer’s disease (AD) is the most common form of dementia among older persons. Pathognomonic hallmarks of the disease include the development of amyloid senile plaques and deposits of neurofibrillary tangles. These ...
Targeting Brain alpha;7 Nicotinic Acetylcholine Receptors in Alzheimer's Disease: Rationale and Current Status.
(Adis Int Ltd, 2014-11)
Alzheimer´s disease (AD) is the most common form of dementia among older persons. Pathognomonic hallmarks of the disease include the development of amyloid senile plaques and deposits of neurofibrillary tangles. These ...
Mechanism of calcium potentiation of the α7 nicotinic acetylcholine receptor
(Rockefeller University Press, 2020-07-23)
The α7 nicotinic acetylcholine receptor (nAChR) is among the most abundant types of nAChR in the brain, yet the ability of nerve-released ACh to activate α7 remains enigmatic. In particular, a major population of α7 resides ...
Lithium causes differential effects on postsynaptic stability in normal and denervated neuromuscular synapses
(Nature Research, 2021-12)
Lithium chloride has been widely used as a therapeutic mood stabilizer. Although cumulative evidence suggests that lithium plays modulatory effects on postsynaptic receptors, the underlying mechanism by which lithium ...
Α7 nicotinic acetylcholine receptor signaling modulates ovine fetal brain astrocytes transcriptome in response to endotoxin
(Frontiers Media S.A., 2019-05)
Neuroinflammation in utero may result in lifelong neurological disabilities. Astrocytes play a pivotal role in this process, but the mechanisms are poorly understood. No early postnatal treatment strategies exist to enhance ...