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Dimer asymmetry and light activation mechanism in brucella blue-light sensor histidine kinase
(American Society for Microbiology, 2021-03)
The ability to sense and respond to environmental cues is essential for adaptation and survival in living organisms. In bacteria, this process is accomplished by multidomain sensor histidine kinases that undergo ...
Reverse Engineering of a Thermosensing Regulator Switch
(Academic Press Ltd - Elsevier Science Ltd, 2019-03)
To address the mechanism of thermosensing and its implications for molecular engineering, we previously deconstructed the functional components of the bacterial thermosensor DesK, a histidine kinase with a five-span ...
Vibrational spectra of the physiologically and pharmacologically relevant Cu(L-His)2 complex
(Colegio de Farmaceuticos de la Provincia de Buenos Aires, 2009)
The infrared spectrum of the Cu(II) complex of L-histidine (L-His) of composition [Cu(LHis)2].1.5 H2O, generated at physiological conditions, was recorded and analyzed in relation to its structural peculiarities and by ...
A genetic screen for mutations affecting temperature sensing in Bacillus subtilis
(Society for General Microbiology, 2019-01)
Two component systems, composed of a receptor histidine kinase and a cytoplasmic response regulator, regulate pivotal cellular processes in microorganisms. Here we describe a new screening procedure for the identification ...
Histidine-Rich Glycoprotein Inhibits HIV-1 Infection in a pH-Dependent Manner
(American Society for Microbiology, 2019-02)
Histidine-rich glycoprotein (HRG) is an abundant plasma protein with a multidomain structure, allowing its interaction with many ligands, including phospholipids, plasminogen, fibrinogen, IgG antibodies, and heparan sulfate. ...
Interaction of glycine, lysine, proline and histidine with dipalmitoylphosphatidylcholine lipid bilayers: a theoretical and experimental study
(Royal Society of Chemistry, 2015-05)
The interaction of unblocked glycine, lysine, proline, and histidine (in their three forms, namely two tautomers and the protonated form) with a dipalmitoylphosphatidylcholine (DPPC) bilayer was assessed using extensive ...
Interhelical h-bonds modulate the activity of a polytopic transmembrane kinase
(Multidisciplinary Digital Publishing Institute, 2021-07)
DesK is a Histidine Kinase that allows Bacillus subtilis to maintain lipid homeostasis in response to changes in the environment. It is located in the membrane, and has five transmembrane helices and a cytoplasmic catalytic ...
Prolonged histamine deficiency in histidine decarboxylase gene knockout mice affects Leydig cell function
(American Society of Andrology, 2007-01)
The present study focuses on histaminergic regulation of Leydig cell physiology, since limited information is available so far. To evaluate the dependency of Leydig cells on histamine (HA), we performed experiments using ...
Driving the catalytic activity of a transmembrane thermosensor kinase
(Birkhauser Verlag Ag, 2020-10)
DesK is a Bacillus thermosensor kinase that is inactive at high temperatures but turns activated when the temperature drops below 25 °C. Surprisingly, the catalytic domain (DesKC) lacking the transmembrane region is more ...
A transmembrane histidine kinase functions as a pH sensor
(Multidisciplinary Digital Publishing Institute, 2020-08)
The two-component system DesK-DesR regulates the synthesis of unsaturated fatty acids in the soil bacteria Bacillus subtilis. This system is activated at low temperature and maintains membrane lipid fluidity upon temperature ...