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Mostrando ítems 1061-1069 de 1069
Defective removal of ribonucleotides from DNA promotes systemic autoimmunity
(American Society for Clinical Investigation, 2015-01)
Genome integrity is continuously challenged by the DNA damage that arises during normal cell metabolism. Biallelic mutations in the genes encoding the genome surveillance enzyme ribonuclease H2 (RNase H2) cause Aicardi-Goutières ...
The ellagic acid metabolites urolithin A and B differentially affect growth, adhesion, motility, and invasion of endometriotic cells in vitro
(NLM (Medline), 2021-03)
STUDY QUESTION: What are the effects of plant-derived antioxidant compounds urolithin A (UA) and B (UB) on the growth and pathogenetic properties of an in vitro endometriosis model? SUMMARY ANSWER: Both urolithins showed ...
Regulación de la función esteroidogénica en testículo y glándula adrenalRegulation of steroidogenic function in testis and adrenal glandRegulação da função esteroidogênica em testículo e glândula adrenal
(Federación Bioquímica de la Provincia Buenos Aires, 2011-12)
Si bien las hormonas hipofisarias LH y ACTH son los reguladores primarios de la esteroidogénesis tanto en células de Leydig (CL) como en la zona fasciculada (ZF) adrenal, respectivamente, evidencias crecientes indican que ...
Cyps molecular biomarkers in rainbow trout Oncorhynchus mykiss to assess oil contamination in a patagonian stream
(Universidad Nacional Autónoma de México. Centro Ciencias de la Atmósfera, 2017-05)
Cytochrome P450 (CYP) gene expressions were studied by semi-quantitative polymerase chain reaction (PCR) to assess oil pollution using liver and gills of juvenile rainbow trout Oncorhynchus mykiss sampled from La Mina ...
A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity
(Springer, 2019-05-26)
The genetic variant rs72824905-G (minor allele) in the PLCG2 gene was previously associated with a reduced Alzheimer’s disease risk (AD). The role of PLCG2 in immune system signaling suggests it may also protect against ...
Scientific Merits and Analytical Challenges of Tree‐Ring Densitometry
(American Geophysical Union, 2019-12)
X-ray microdensitometry on annually resolved tree-ring samples has gained an exceptional position in last-millennium paleoclimatology through the maximum latewood density (MXD) parameter, but also increasingly through other ...
Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases
(American Society for Clinical Investigation, 2020-04)
BACKGROUND. Undifferentiated systemic autoinflammatory diseases (USAIDs) present diagnostic and therapeutic challenges. Chronic interferon (IFN) signaling and cytokine dysregulation may identify diseases with available ...