Buscar
Mostrando ítems 1-10 de 1069
Estrogen receptors and signaling pathways in lactotropes and somatotropes
(Karger, 2010-12)
Estrogens are crucial determinants in the regulation of anterior pituitary function and maintenance of tissue homeostasis. Estrogen actions in this gland are exerted through both classical and non-classical mechanisms of ...
Docosahexaenoic acid prevents apoptosis of retina photoreceptors by activating the ERK/MAPK pathway
(Wiley Blackwell Publishing, Inc, 2006-07-26)
Identifying the trophic factors for retina photoreceptors and the intracellular pathways activated to promote cell survival is crucial for treating retina neurodegenerative diseases. Docosahexaenoic acid (DHA), the major ...
Long Signaling Cascades Tend to Attenuate Retroactivity
(Cell Press, 2011-04)
Signaling pathways consisting of phosphorylation/dephosphorylation cycles with no explicit feedback allow signals to propagate not only from upstream to downstream but also from downstream to upstream due to retroactivity ...
G protein-coupled receptor signal transduction and Ca2+ signaling pathways of the allatotropin/orexin system in Hydra
(Academic Press Inc Elsevier Science, 2021-01-01)
Allatotropin is a pleiotropic peptide originally characterized in insects. The existence of AT neuropeptide signaling was proposed in other invertebrates. In fact, we previously proposed the presence of an AT-like system ...
Persistent activation of the mammalian target of rapamycin signaling pathway in cutaneous squamous cell carcinomas in cats
(Wiley Blackwell Publishing, Inc, 2021-07)
Background: Cutaneous squamous cell carcinoma (CSCC) represents the most common malignant tumour of the feline skin. Emerging evidence suggests that the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin ...
Cross-talk between mitochondrial function, growth, and stress signalling pathways in plants
(Oxford University Press, 2020-12)
Plant mitochondria harbour complex metabolic routes that are interconnected with those of other cell compartments and changes in mitochondrial function remotely influence processes in different parts of the cell. This ...
Glypican-3 reexpression regulates apoptosis in murine adenocarcinoma mammary cells modulating PI3K/Akt and p38MAPK signaling pathways
(Springer, 2010-02)
Glypican-3 (GPC3) is a proteoglycan involved in proliferation and cell survival. Several reports demonstrated that GPC3 is downregulated in some tumors, such as breast cancer. Previously, we determined that GPC3 reexpression ...
Synthetic stigmastanes with dual antiherpetic and immunomodulating activities inhibit ERK and Akt signaling pathways without binding to glucocorticoid receptors
(Elsevier Science, 2016-01)
Background: We have previously shown that some synthetic hydroxylated stigmastanes derived from plant sterols inhibit in vitro HSV-1 replication in ocular cell lines and decrease cytokine production in stimulated macrophages, ...
Integration of Plasma Membrane and Nuclear Signaling in Elicitor Regulation of Plant Secondary Metabolism
(Natural Products, 2008-08-01)
The plant kingdom represents a valuable source of natural products of commercial interest. These compounds, named secondary metabolites, are not essential for the survival of plants, but confer them some advantages that ...
Retrograde bone morphogenetic protein signaling shapes a key circadian pacemaker circuit
(Society For Neuroscience, 2013-01)
The neuropeptide pigment-dispersing factor (PDF) synchronizes molecular oscillations within circadian pacemakers in the Drosophila brain. It is expressed in the small ventral lateral neurons (sLNvs) and large ventral lateral ...