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Bioavailability of butorphanol after intranasal administration to horses
(Trakia University, 2020-12)
The aim of the present study was to describe butorphanol pharmacokinetics and bioavailability following intranasal administration to horses. Six adult horses received 0.05 mg/kg butorphanol, in a randomised crossover design, ...
Impact of water hardness on oxytetracycline oral bioavailability in fed and fasted piglets
(Wiley Blackwell Publishing, Inc, 2019-07)
Water hardness is a critical factor that affects oxytetracycline dissolution by chelation with cations. These interactions may lead to impaired dosing and consequently decrease absorption. Moreover, feed present in ...
Effect of genotype and sex of the host on the bioavailability of novel albendazole microcrystals based on chitosan and cellulose derivatives
(Springer, 2020-05)
Albendazole (ABZ), an anthelmintic compound widely used in the treatment of systemic nematode infections, is included in the list of class II drugs based on the Biopharmaceutical Classification System. ABZ has limited ...
The use of saliva as a biological fluid in relative bioavailability studies: Comparison and correlation with plasma results
(John Wiley & Sons Ltd, 2010-11)
The aim of the present study was to present new evidence supporting the use of saliva as a biological fluid in relative bioavailability studies. Carbamazepine was chosen as a model drug because of its suitability for ...
Potential interactions between an oral fosfomycin formulation and feed or drinking water: Impact on bioavailability in piglets
(Wiley Blackwell Publishing, Inc, 2021-03)
Feed and drinking water are the most frequently used vehicles for administration of antibiotics in intensive pig production. Interactions of drugs with feed and water components may affect dissolution and bioavailability. ...
Enhanced intestinal permeability and oral bioavailability of enalapril maleate upon complexation with the cationic polymethacrylate Eudragit E100
(Elsevier Science, 2014-05)
The low bioavailability of enalapril maleate associated to its instability in solid state motivated the development of a polyelectrolyte-drug complex between enalapril maleate and the cationic polymethacrylate Eudragit ...
Toxicity and bioavailability of mercury in spiked sediments on Hyalella curvispina Shoemaker, 1942
(Inderscience Enterprises, 2013)
Whey proteins-folic acid complexes: Formation, isolation and bioavailability in a Lactobacillus casei model
(Elsevier, 2020-10)
The objective of this work was to explore the complexation of a whey protein (β-lactoglobulin, β-lg) and a whey protein isolate (WPI) with folic acid (FA) at pH 3.0. Complexes were formed through non-covalent interactions, ...
Evaluation of the bioavailability and intestinal effects of milk fermented by folate producing lactic acid bacteria in a depletion/repletion mice model
(Elsevier, 2020-03)
This study aimed to evaluate the bioavailability and effects on the intestinal mucosa of a bioenriched fermented milk (BFM) prepared with folate-producing lactic acid bacteria, using a depletion/repletion BALB/c mice model. ...
Solid dispersion technology as a strategy to improve the bioavailability of poorly soluble drugs
(Future Medicine, 2019-05)
Over the last half-century, solid dispersions (SDs) have been intensively investigated as a strategy to improve drugs solubility and dissolution rate, enhancing oral bioavailability. In this review, an overview of the state ...