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Inhibition of HIV-1 Replication in Human Monocyte-Derived Macrophages by Parasite Trypanosoma cruzi
(Public Library of Science, 2009-12)
Background: Cells of monocyte/macrophage lineage are one of the major targets of HIV-1 infection and serve as reservoirs for viral persistence in vivo. These cells are also the target of the protozoa Trypanosoma cruzi, the ...
CYP26B1 declines postnatally in Sertoli cells independently of androgen action in the mouse testis
(Wiley-liss, div John Wiley & Sons Inc., 2019-11)
Meiosis begins at puberty and relies on several factors, including androgens and retinoic acid in the mouse testis. CYP26B1 degrades retinoic acid in the testis during prenatal development preventing meiosis initiation. ...
Therapeutic improvement of a stroma-targeted CRAd by incorporating motives responsive to melanoma microenvironment
(Williams & Wilkins, 2013-11)
We have previously designed a conditionally replicative oncolytic adenovirus (CRAd) named Ad-F512 that can target both the stromal and the malignant melanoma cell compartments. The replication capacity of this CRAd is ...
Synthesis and activity evaluation of a series of cholanamides as modulators of the liver X receptors
(Pergamon-Elsevier Science Ltd, 2018-03)
The Liver X receptors (LXRs) are members of the nuclear receptor family, that play fundamental roles in cholesterol transport, lipid metabolism and modulation of inflammatory responses. In recent years, the synthetic steroid ...
Action modes of the immune modulating activities of crude mushroom polysaccharide from Phallus atrovolvatus
(Elsevier, 2020-07)
Phallus atrovolvatus is a wild edible mushroom which is recently being cultivated in Thailand. It contains a remarkable amount of β-(1,3–1,6)-glucan, a compound known for its immune modulating properties. Crude mushroom ...
Androgens downregulate anti-Müllerian hormone promoter activity in the Sertoli cell through the androgen receptor and intact steroidogenic factor 1 sites
(Society for the Study of Reproduction, 2018-12)
Testicular anti-Müllerian hormone (AMH) production is inhibited by androgens around pubertal onset, as observed under normal physiological conditions and in patients with precocious puberty. In agreement, AMH downregulation ...
Peptides of amaranth were targeted as containing sequences with potential anti-inflammatory properties
(Elsevier, 2016-03)
The immunomodulatory effect of amaranth peptides on epithelial cells activated through the NF-κB signalling pathway was examined. Results showed that extensive protein hydrolysis from amaranth (23 and 30% degree of hydrolysis) ...
Activation of Adenylyl Cyclase Causes Stimulation of Adenosine Receptors
(Karger, 2018-05)
AbstractBACKGROUND/AIMS:Signaling of Gs protein-coupled receptors (GsPCRs) is accomplished by stimulation of adenylyl cyclase, causing an increase of the intracellular cAMP concentration, activation of the intracellular ...
Down-regulation of NF-κB signaling by Gordonia bronchialis prevents the activation of gut epithelial cells
(Sage Publications Ltd, 2014-08)
The immunomodulatory power of heat-killed Gordonia bronchialis was studied on gut epithelial cells activated with pro-inflammatory stimuli (flagellin, TNF-α or IL-1β). Light emission of luciferase-transfected epithelial ...
Up-regulation of placental leptin by human chorionic gonadotropin
(Endocrine Society, 2009-01)
Leptin, the 16,000 molecular weight protein product of the obese gene, was originally considered as an adipocyte-derived signaling molecule for the central control of metabolism. However, leptin has been suggested to be ...